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Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy

BACKGROUND: Laparoscopic cholecystectomy is associated with shorter hospital stay and less pain in comparison to open surgery. The aim of this study was to evaluate the effect of intraperitoneal hydrocortisone on pain relief following laparoscopic cholecystectomy. METHODS: Sixty two patients were en...

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Autores principales: Sarvestani, Amene S., Amini, Shahram, Kalhor, Mohsen, Roshanravan, Reza, Mohammadi, Mehdi, Lebaschi, Amir Hussein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657916/
https://www.ncbi.nlm.nih.gov/pubmed/23717225
http://dx.doi.org/10.4103/1658-354X.109799
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author Sarvestani, Amene S.
Amini, Shahram
Kalhor, Mohsen
Roshanravan, Reza
Mohammadi, Mehdi
Lebaschi, Amir Hussein
author_facet Sarvestani, Amene S.
Amini, Shahram
Kalhor, Mohsen
Roshanravan, Reza
Mohammadi, Mehdi
Lebaschi, Amir Hussein
author_sort Sarvestani, Amene S.
collection PubMed
description BACKGROUND: Laparoscopic cholecystectomy is associated with shorter hospital stay and less pain in comparison to open surgery. The aim of this study was to evaluate the effect of intraperitoneal hydrocortisone on pain relief following laparoscopic cholecystectomy. METHODS: Sixty two patients were enrolled in a double-blind, randomized clinical trial. Patients randomly received intraperitoneal instillation of either 250 ml normal saline (n=31) or 100 mg hydrocortisone in 250 ml normal saline (n=31) before insufflation of CO(2) into the peritoneum. Abdominal and shoulder pain were evaluated using VAS after surgery and at 6, 12, and 24 hours postoperatively. The patients were also followed for postoperative analgesic requirements, nausea and vomiting, and return of bowel function. RESULTS: Sixty patients completed the study. Patients in the hydrocortisone group had significantly lower abdominal and shoulder pain scores (10.95 vs 12.95; P<0.01). The patients were similar regarding analgesic requirements in the recovery room. However, those in the hydrocortisone group required less meperidine than the saline group (151.66 (±49.9) mg vs 61.66 (±38.69) mg; P=0.00). The patients were similar with respect to return of bowel function, nausea and vomiting. No adverse reaction was observed in either group. CONCLUSION: Intraperitoneal administration of hydrocortisone can significantly decrease pain and analgesic requirements after laparoscopic cholecystectomy with no adverse effects.
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spelling pubmed-36579162013-05-28 Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy Sarvestani, Amene S. Amini, Shahram Kalhor, Mohsen Roshanravan, Reza Mohammadi, Mehdi Lebaschi, Amir Hussein Saudi J Anaesth Original Article BACKGROUND: Laparoscopic cholecystectomy is associated with shorter hospital stay and less pain in comparison to open surgery. The aim of this study was to evaluate the effect of intraperitoneal hydrocortisone on pain relief following laparoscopic cholecystectomy. METHODS: Sixty two patients were enrolled in a double-blind, randomized clinical trial. Patients randomly received intraperitoneal instillation of either 250 ml normal saline (n=31) or 100 mg hydrocortisone in 250 ml normal saline (n=31) before insufflation of CO(2) into the peritoneum. Abdominal and shoulder pain were evaluated using VAS after surgery and at 6, 12, and 24 hours postoperatively. The patients were also followed for postoperative analgesic requirements, nausea and vomiting, and return of bowel function. RESULTS: Sixty patients completed the study. Patients in the hydrocortisone group had significantly lower abdominal and shoulder pain scores (10.95 vs 12.95; P<0.01). The patients were similar regarding analgesic requirements in the recovery room. However, those in the hydrocortisone group required less meperidine than the saline group (151.66 (±49.9) mg vs 61.66 (±38.69) mg; P=0.00). The patients were similar with respect to return of bowel function, nausea and vomiting. No adverse reaction was observed in either group. CONCLUSION: Intraperitoneal administration of hydrocortisone can significantly decrease pain and analgesic requirements after laparoscopic cholecystectomy with no adverse effects. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3657916/ /pubmed/23717225 http://dx.doi.org/10.4103/1658-354X.109799 Text en Copyright: © Saudi Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sarvestani, Amene S.
Amini, Shahram
Kalhor, Mohsen
Roshanravan, Reza
Mohammadi, Mehdi
Lebaschi, Amir Hussein
Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy
title Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy
title_full Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy
title_fullStr Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy
title_full_unstemmed Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy
title_short Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy
title_sort intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657916/
https://www.ncbi.nlm.nih.gov/pubmed/23717225
http://dx.doi.org/10.4103/1658-354X.109799
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