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Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats
OBJECTIVE: This study aims to elucidate the effect of Ocimum gratissimum on hematological parameters in rats. MATERIALS AND METHODS: Thirty male albino Wistar rats were randomly assigned into three groups of ten rats each. Group 1 was control, while groups 2 (LD) and 3 (HD) received 500 mg/kg and 10...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657984/ https://www.ncbi.nlm.nih.gov/pubmed/23776807 http://dx.doi.org/10.4103/2229-516X.96807 |
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author | Ofem, OE Ani, EJ Eno, AE |
author_facet | Ofem, OE Ani, EJ Eno, AE |
author_sort | Ofem, OE |
collection | PubMed |
description | OBJECTIVE: This study aims to elucidate the effect of Ocimum gratissimum on hematological parameters in rats. MATERIALS AND METHODS: Thirty male albino Wistar rats were randomly assigned into three groups of ten rats each. Group 1 was control, while groups 2 (LD) and 3 (HD) received 500 mg/kg and 1000 mg/kg body weight, respectively, of the extract orally once daily. Rats in all three groups received normal rat chow and drinking water ad libitum for 28 days. Complete blood count was done using an automatic counter. RESULTS: The HD group had significantly (P<.05) higher red blood cell (RBC) counts, packed cell volume (PCV), hemoglobin (Hb), and platelet counts as compared with the control and LD groups. No significant changes were observed in the total white blood cell (WBC) count of the three groups, but significantly (P<.05) lower lymphocyte and higher neutrophil counts were observed in the HD group compared with the LD group. The mean platelet volume (MPV), platelet–large cell ratio (P–LCR), and platelet distribution width (PDW) were significantly (P<.05) reduced in the HD compared with the LD group. The mean corpuscular volume (MCV) and RBC distribution width–standard deviation were significantly (P<.05) lower in the HD group than in control. No significant changes were observed in levels of mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and RBC distribution width–coefficient of variation among the groups. CONCLUSION: We conclude that oral administration of O gratissimum increases RBC, PCV, Hb, platelet count, and neutrophils and also leads to a decrease in platelet indices (i.e., MPV, P–LCR, and PDW). |
format | Online Article Text |
id | pubmed-3657984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36579842013-06-17 Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats Ofem, OE Ani, EJ Eno, AE Int J Appl Basic Med Res Original Article OBJECTIVE: This study aims to elucidate the effect of Ocimum gratissimum on hematological parameters in rats. MATERIALS AND METHODS: Thirty male albino Wistar rats were randomly assigned into three groups of ten rats each. Group 1 was control, while groups 2 (LD) and 3 (HD) received 500 mg/kg and 1000 mg/kg body weight, respectively, of the extract orally once daily. Rats in all three groups received normal rat chow and drinking water ad libitum for 28 days. Complete blood count was done using an automatic counter. RESULTS: The HD group had significantly (P<.05) higher red blood cell (RBC) counts, packed cell volume (PCV), hemoglobin (Hb), and platelet counts as compared with the control and LD groups. No significant changes were observed in the total white blood cell (WBC) count of the three groups, but significantly (P<.05) lower lymphocyte and higher neutrophil counts were observed in the HD group compared with the LD group. The mean platelet volume (MPV), platelet–large cell ratio (P–LCR), and platelet distribution width (PDW) were significantly (P<.05) reduced in the HD compared with the LD group. The mean corpuscular volume (MCV) and RBC distribution width–standard deviation were significantly (P<.05) lower in the HD group than in control. No significant changes were observed in levels of mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and RBC distribution width–coefficient of variation among the groups. CONCLUSION: We conclude that oral administration of O gratissimum increases RBC, PCV, Hb, platelet count, and neutrophils and also leads to a decrease in platelet indices (i.e., MPV, P–LCR, and PDW). Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3657984/ /pubmed/23776807 http://dx.doi.org/10.4103/2229-516X.96807 Text en Copyright: © International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ofem, OE Ani, EJ Eno, AE Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats |
title | Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats |
title_full | Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats |
title_fullStr | Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats |
title_full_unstemmed | Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats |
title_short | Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats |
title_sort | effect of aqueous leaves extract of ocimum gratissimum on hematological parameters in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657984/ https://www.ncbi.nlm.nih.gov/pubmed/23776807 http://dx.doi.org/10.4103/2229-516X.96807 |
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