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Efficacy of the β(2)-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

Many drugs that target G-protein-coupled receptors (GPCRs) induce or inhibit their signal transduction with different strengths, which affect their therapeutic properties. However, the mechanism underlying the differences in the signalling levels is still not clear, although several structures of GP...

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Detalles Bibliográficos
Autores principales:	Kofuku, Yutaka, Ueda, Takumi, Okude, Junya, Shiraishi, Yutaro, Kondo, Keita, Maeda, Masahiro, Tsujishita, Hideki, Shimada, Ichio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658005/ https://www.ncbi.nlm.nih.gov/pubmed/22948827 http://dx.doi.org/10.1038/ncomms2046

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