Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

Mast cells are known effector cells in allergic and inflammatory diseases, but their precise roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in intestinal inflammation is mediated by ATP-reactive P2X7 purinoceptors. We find an increase in the numbers of ma...

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Detalles Bibliográficos
Autores principales: Kurashima, Yosuke, Amiya, Takeaki, Nochi, Tomonori, Fujisawa, Kumiko, Haraguchi, Takeshi, Iba, Hideo, Tsutsui, Hiroko, Sato, Shintaro, Nakajima, Sachiko, Iijima, Hideki, Kubo, Masato, Kunisawa, Jun, Kiyono, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658010/
https://www.ncbi.nlm.nih.gov/pubmed/22948816
http://dx.doi.org/10.1038/ncomms2023

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