A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets

A simple HPTLC method having high accuracy, precision and reproducibility was developed for the routine estimation of moxifloxacin hydrochloride in the tablets available in market and was validated for various parameters according to ICH guidelines. moxifloxacin hydrochloride was estimated at 292 nm...

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Detalles Bibliográficos
Autores principales: Dhillon, Vandana, Chaudhary, Alok Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658017/
https://www.ncbi.nlm.nih.gov/pubmed/23781417
http://dx.doi.org/10.4103/2229-4708.72232
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author Dhillon, Vandana
Chaudhary, Alok Kumar
author_facet Dhillon, Vandana
Chaudhary, Alok Kumar
author_sort Dhillon, Vandana
collection PubMed
description A simple HPTLC method having high accuracy, precision and reproducibility was developed for the routine estimation of moxifloxacin hydrochloride in the tablets available in market and was validated for various parameters according to ICH guidelines. moxifloxacin hydrochloride was estimated at 292 nm by densitometry using Silica gel 60 F(254) as stationary phase and a premix of methylene chloride: methanol: strong ammonia solution and acetonitrile (10:10:5:10) as mobile phase. Method was found linear in a range of 9-54 nanograms with a correlation coefficient >0.99. The regression equation was: AUC = 65.57 × (Amount in nanograms) + 163 (r(2) = 0.9908).
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spelling pubmed-36580172013-06-18 A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets Dhillon, Vandana Chaudhary, Alok Kumar Pharm Methods Original Article A simple HPTLC method having high accuracy, precision and reproducibility was developed for the routine estimation of moxifloxacin hydrochloride in the tablets available in market and was validated for various parameters according to ICH guidelines. moxifloxacin hydrochloride was estimated at 292 nm by densitometry using Silica gel 60 F(254) as stationary phase and a premix of methylene chloride: methanol: strong ammonia solution and acetonitrile (10:10:5:10) as mobile phase. Method was found linear in a range of 9-54 nanograms with a correlation coefficient >0.99. The regression equation was: AUC = 65.57 × (Amount in nanograms) + 163 (r(2) = 0.9908). Medknow Publications & Media Pvt Ltd 2010 /pmc/articles/PMC3658017/ /pubmed/23781417 http://dx.doi.org/10.4103/2229-4708.72232 Text en Copyright: © Pharmaceutical Methods http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dhillon, Vandana
Chaudhary, Alok Kumar
A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets
title A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets
title_full A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets
title_fullStr A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets
title_full_unstemmed A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets
title_short A validated HPTLC method for estimation of moxifloxacin hydrochloride in tablets
title_sort validated hptlc method for estimation of moxifloxacin hydrochloride in tablets
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658017/
https://www.ncbi.nlm.nih.gov/pubmed/23781417
http://dx.doi.org/10.4103/2229-4708.72232
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