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Bioanalysis in drug discovery and development
Recent years have witnessed the introduction of several high-quality review articles into the literature covering various scientific and technical aspects of bioanalysis. Now it is widely accepted that bioanalysis is an integral part of the pharmacokinetic/pharmacodynamic characterization of a novel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658019/ https://www.ncbi.nlm.nih.gov/pubmed/23781412 http://dx.doi.org/10.4103/2229-4708.72223 |
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author | Pandey, Saurabh Pandey, Preeti Tiwari, Gaurav Tiwari, Ruchi |
author_facet | Pandey, Saurabh Pandey, Preeti Tiwari, Gaurav Tiwari, Ruchi |
author_sort | Pandey, Saurabh |
collection | PubMed |
description | Recent years have witnessed the introduction of several high-quality review articles into the literature covering various scientific and technical aspects of bioanalysis. Now it is widely accepted that bioanalysis is an integral part of the pharmacokinetic/pharmacodynamic characterization of a novel chemical entity from the time of its discovery and during various stages of drug development, leading to its market authorization. In this compilation, the important bioanalytical parameters and its application to drug discovery and development approaches are discussed, which will help in the development of safe and more efficacious drugs with reduced development time and cost. It is intended to give some general thoughts in this area which will form basis of a general framework as to how one would approach bioanalysis from inception (i.e., discovery of a lead molecule) and progressing through various stages of drug development. |
format | Online Article Text |
id | pubmed-3658019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36580192013-06-18 Bioanalysis in drug discovery and development Pandey, Saurabh Pandey, Preeti Tiwari, Gaurav Tiwari, Ruchi Pharm Methods Review Article Recent years have witnessed the introduction of several high-quality review articles into the literature covering various scientific and technical aspects of bioanalysis. Now it is widely accepted that bioanalysis is an integral part of the pharmacokinetic/pharmacodynamic characterization of a novel chemical entity from the time of its discovery and during various stages of drug development, leading to its market authorization. In this compilation, the important bioanalytical parameters and its application to drug discovery and development approaches are discussed, which will help in the development of safe and more efficacious drugs with reduced development time and cost. It is intended to give some general thoughts in this area which will form basis of a general framework as to how one would approach bioanalysis from inception (i.e., discovery of a lead molecule) and progressing through various stages of drug development. Medknow Publications & Media Pvt Ltd 2010 /pmc/articles/PMC3658019/ /pubmed/23781412 http://dx.doi.org/10.4103/2229-4708.72223 Text en Copyright: © Pharmaceutical Methods http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pandey, Saurabh Pandey, Preeti Tiwari, Gaurav Tiwari, Ruchi Bioanalysis in drug discovery and development |
title | Bioanalysis in drug discovery and development |
title_full | Bioanalysis in drug discovery and development |
title_fullStr | Bioanalysis in drug discovery and development |
title_full_unstemmed | Bioanalysis in drug discovery and development |
title_short | Bioanalysis in drug discovery and development |
title_sort | bioanalysis in drug discovery and development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658019/ https://www.ncbi.nlm.nih.gov/pubmed/23781412 http://dx.doi.org/10.4103/2229-4708.72223 |
work_keys_str_mv | AT pandeysaurabh bioanalysisindrugdiscoveryanddevelopment AT pandeypreeti bioanalysisindrugdiscoveryanddevelopment AT tiwarigaurav bioanalysisindrugdiscoveryanddevelopment AT tiwariruchi bioanalysisindrugdiscoveryanddevelopment |