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Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets

AIM: Three simple, accurate, and reproducible spectrophotometric methods have been developed and validated for simultaneous estimation of telmisartan (TELM) atorvastatin (ATV) in combined tablet dosage form. MATERIALS AND METHODS: The first method is based on first-order derivative spectroscopy. The...

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Autores principales: Ilango, Kaliappan, Kumar, Pushpangadhan S. Shiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658084/
https://www.ncbi.nlm.nih.gov/pubmed/23781490
http://dx.doi.org/10.4103/2229-4708.103892
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author Ilango, Kaliappan
Kumar, Pushpangadhan S. Shiji
author_facet Ilango, Kaliappan
Kumar, Pushpangadhan S. Shiji
author_sort Ilango, Kaliappan
collection PubMed
description AIM: Three simple, accurate, and reproducible spectrophotometric methods have been developed and validated for simultaneous estimation of telmisartan (TELM) atorvastatin (ATV) in combined tablet dosage form. MATERIALS AND METHODS: The first method is based on first-order derivative spectroscopy. The sampling wavelengths were 223 nm (zero crossing of TELM) where ATV showed considerable absorbance and 272 nm (zero crossing of ATV) where TELM showed considerable absorbance. The second method Q-analysis (absorbance ratio), involves formation of Q-absorbance equation using respective absorptivity values at 280.9 nm (isobestic point) and 296.0 nm (λmax of TELM). The third method involves determination using multicomponent mode method; sampling wavelengths selected were 296.0 and 246.9 nm. RESULTS: TELM and ATV followed linearity in the concentration range of 5–40 and 4–32 μg/ml for method I, 5–30 μg/ml and 2–24 μg/ml for method II and III, respectively. Mean recoveries for all three methods were found satisfactory. All methods were validated according to International Conference on Harmonization Q2B guidelines. CONCLUSION: The developed methods are simple, precise, rugged, and economical. The utility of methods has been demonstrated by analysis of commercially available tablet dosage form.
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spelling pubmed-36580842013-06-18 Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets Ilango, Kaliappan Kumar, Pushpangadhan S. Shiji Pharm Methods Original Article AIM: Three simple, accurate, and reproducible spectrophotometric methods have been developed and validated for simultaneous estimation of telmisartan (TELM) atorvastatin (ATV) in combined tablet dosage form. MATERIALS AND METHODS: The first method is based on first-order derivative spectroscopy. The sampling wavelengths were 223 nm (zero crossing of TELM) where ATV showed considerable absorbance and 272 nm (zero crossing of ATV) where TELM showed considerable absorbance. The second method Q-analysis (absorbance ratio), involves formation of Q-absorbance equation using respective absorptivity values at 280.9 nm (isobestic point) and 296.0 nm (λmax of TELM). The third method involves determination using multicomponent mode method; sampling wavelengths selected were 296.0 and 246.9 nm. RESULTS: TELM and ATV followed linearity in the concentration range of 5–40 and 4–32 μg/ml for method I, 5–30 μg/ml and 2–24 μg/ml for method II and III, respectively. Mean recoveries for all three methods were found satisfactory. All methods were validated according to International Conference on Harmonization Q2B guidelines. CONCLUSION: The developed methods are simple, precise, rugged, and economical. The utility of methods has been demonstrated by analysis of commercially available tablet dosage form. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3658084/ /pubmed/23781490 http://dx.doi.org/10.4103/2229-4708.103892 Text en Copyright: © Pharmaceutical Methods http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ilango, Kaliappan
Kumar, Pushpangadhan S. Shiji
Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets
title Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets
title_full Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets
title_fullStr Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets
title_full_unstemmed Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets
title_short Validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets
title_sort validated spectrophotometric methods for the simultaneous determination of telmisartan and atorvastatin in bulk and tablets
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658084/
https://www.ncbi.nlm.nih.gov/pubmed/23781490
http://dx.doi.org/10.4103/2229-4708.103892
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