SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits

Measurement error and biological variability generate distortions in quantitative phenotypic data. In longitudinal studies with repeated measurements, the multiple measurements provide a route to reduce noise and correspondingly increase the strength of signals in genome-wide association studies (GW...

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Detalles Bibliográficos
Autores principales: Meirelles, Osorio D, Ding, Jun, Tanaka, Toshiko, Sanna, Serena, Yang, Hsih-Te, Dudekula, Dawood B, Cucca, Francesco, Ferrucci, Luigi, Abecasis, Goncalo, Schlessinger, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658185/
https://www.ncbi.nlm.nih.gov/pubmed/23092954
http://dx.doi.org/10.1038/ejhg.2012.215

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