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Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection?

Background. The hygiene hypothesis suggests that high hygiene standards have led to an immune dysfunction and an increase in allergic diseases. Farming-related exposures are associated with a decreased risk of asthma. Since the gut microbiota may be a pivotal component in the hygiene hypothesis, we...

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Autores principales: Nermes, Merja, Niinivirta, Katri, Nylund, Lotta, Laitinen, Kirsi, Matomäki, Jaakko, Salminen, Seppo, Isolauri, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658390/
https://www.ncbi.nlm.nih.gov/pubmed/23724248
http://dx.doi.org/10.1155/2013/827934
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author Nermes, Merja
Niinivirta, Katri
Nylund, Lotta
Laitinen, Kirsi
Matomäki, Jaakko
Salminen, Seppo
Isolauri, Erika
author_facet Nermes, Merja
Niinivirta, Katri
Nylund, Lotta
Laitinen, Kirsi
Matomäki, Jaakko
Salminen, Seppo
Isolauri, Erika
author_sort Nermes, Merja
collection PubMed
description Background. The hygiene hypothesis suggests that high hygiene standards have led to an immune dysfunction and an increase in allergic diseases. Farming-related exposures are associated with a decreased risk of asthma. Since the gut microbiota may be a pivotal component in the hygiene hypothesis, we studied whether perinatal exposure to pets, doctor's diagnosed wheezy bronchitis (WB), and compositional changes in the gut microbiota are interrelated among urban infants. Methods. Data were collected prospectively from a mother-infant nutrition study. Data on perinatal pet ownership, WB, and the microbiota composition of faecal samples of the infants assessed by quantitative PCR at 1 month were compared. Results. None of the 30 infants exposed to pets had suffered from WB by 24 months, whereas 15 of the 99 (15%) nonexposed infants had had WB (P = 0.03). The counts of Bifidobacterium longum were higher in samples (n = 17) from nonwheezing infants with pet exposure compared to those (n = 10) in wheezing infants without pet exposure (8.59/10.44 versus 5.94/9.86, resp. (median/upper limit of range, bacteria(log)/g of stool); P = 0.02). B. breve was more abundant in the wheezing infants (P = 0.02).
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spelling pubmed-36583902013-05-30 Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection? Nermes, Merja Niinivirta, Katri Nylund, Lotta Laitinen, Kirsi Matomäki, Jaakko Salminen, Seppo Isolauri, Erika ISRN Allergy Research Article Background. The hygiene hypothesis suggests that high hygiene standards have led to an immune dysfunction and an increase in allergic diseases. Farming-related exposures are associated with a decreased risk of asthma. Since the gut microbiota may be a pivotal component in the hygiene hypothesis, we studied whether perinatal exposure to pets, doctor's diagnosed wheezy bronchitis (WB), and compositional changes in the gut microbiota are interrelated among urban infants. Methods. Data were collected prospectively from a mother-infant nutrition study. Data on perinatal pet ownership, WB, and the microbiota composition of faecal samples of the infants assessed by quantitative PCR at 1 month were compared. Results. None of the 30 infants exposed to pets had suffered from WB by 24 months, whereas 15 of the 99 (15%) nonexposed infants had had WB (P = 0.03). The counts of Bifidobacterium longum were higher in samples (n = 17) from nonwheezing infants with pet exposure compared to those (n = 10) in wheezing infants without pet exposure (8.59/10.44 versus 5.94/9.86, resp. (median/upper limit of range, bacteria(log)/g of stool); P = 0.02). B. breve was more abundant in the wheezing infants (P = 0.02). Hindawi Publishing Corporation 2013-01-09 /pmc/articles/PMC3658390/ /pubmed/23724248 http://dx.doi.org/10.1155/2013/827934 Text en Copyright © 2013 Merja Nermes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nermes, Merja
Niinivirta, Katri
Nylund, Lotta
Laitinen, Kirsi
Matomäki, Jaakko
Salminen, Seppo
Isolauri, Erika
Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection?
title Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection?
title_full Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection?
title_fullStr Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection?
title_full_unstemmed Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection?
title_short Perinatal Pet Exposure, Faecal Microbiota, and Wheezy Bronchitis: Is There a Connection?
title_sort perinatal pet exposure, faecal microbiota, and wheezy bronchitis: is there a connection?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658390/
https://www.ncbi.nlm.nih.gov/pubmed/23724248
http://dx.doi.org/10.1155/2013/827934
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