Cargando…
Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radica...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658412/ https://www.ncbi.nlm.nih.gov/pubmed/23724298 http://dx.doi.org/10.1155/2013/459530 |
_version_ | 1782270269481549824 |
---|---|
author | Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P. |
author_facet | Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P. |
author_sort | Quintans-Júnior, Lucindo |
collection | PubMed |
description | Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate. |
format | Online Article Text |
id | pubmed-3658412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36584122013-05-30 Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P. ISRN Toxicol Research Article Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate. Hindawi Publishing Corporation 2013-01-14 /pmc/articles/PMC3658412/ /pubmed/23724298 http://dx.doi.org/10.1155/2013/459530 Text en Copyright © 2013 Lucindo Quintans-Júnior et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Quintans-Júnior, Lucindo Moreira, José C. F. Pasquali, Matheus A. B. Rabie, Soheyla M. S. Pires, André S. Schröder, Rafael Rabelo, Thallita K. Santos, João P. A. Lima, Pollyana S. S. Cavalcanti, Sócrates C. H. Araújo, Adriano A. S. Quintans, Jullyana S. S. Gelain, Daniel P. Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title | Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_full | Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_fullStr | Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_full_unstemmed | Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_short | Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
title_sort | antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658412/ https://www.ncbi.nlm.nih.gov/pubmed/23724298 http://dx.doi.org/10.1155/2013/459530 |
work_keys_str_mv | AT quintansjuniorlucindo antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT moreirajosecf antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT pasqualimatheusab antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT rabiesoheylams antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT piresandres antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT schroderrafael antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT rabelothallitak antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT santosjoaopa antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT limapollyanass antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT cavalcantisocratesch antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT araujoadrianoas antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT quintansjullyanass antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels AT gelaindanielp antinociceptiveactivityandredoxprofileofthemonoterpenescamphenepcymeneandgeranylacetateinexperimentalmodels |