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Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma

BACKGROUND: Lenalidomide is an active immunomodulatory and antiproliferative agent in multiple myeloma. However, the molecular mechanisms driving these activities are not yet fully elucidated. Therefore, we investigated the modulation of the cytokine/growth factor patterns of myeloma cells under LEN...

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Autores principales: Maïga, S, Gomez-Bougie, P, Bonnaud, S, Gratas, C, Moreau, P, Le Gouill, S, Pellat-Deceunynck, C, Amiot, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658519/
https://www.ncbi.nlm.nih.gov/pubmed/23632478
http://dx.doi.org/10.1038/bjc.2013.186
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author Maïga, S
Gomez-Bougie, P
Bonnaud, S
Gratas, C
Moreau, P
Le Gouill, S
Pellat-Deceunynck, C
Amiot, M
author_facet Maïga, S
Gomez-Bougie, P
Bonnaud, S
Gratas, C
Moreau, P
Le Gouill, S
Pellat-Deceunynck, C
Amiot, M
author_sort Maïga, S
collection PubMed
description BACKGROUND: Lenalidomide is an active immunomodulatory and antiproliferative agent in multiple myeloma. However, the molecular mechanisms driving these activities are not yet fully elucidated. Therefore, we investigated the modulation of the cytokine/growth factor patterns of myeloma cells under LEN treatment. METHODS: Lenalidomide effect on myeloma cell proliferation was investigated in a myeloma cell line collection (n=23) by (3)H-thymidine incorporation. Modulation of the cytokine/growth factor patterns of myeloma cells under LEN treatment was analysed by real-time quantitative PCR. RESULTS: Lenalidomide inhibits the proliferation of two-thirds of myeloma cell lines independently of their genetic background. We demonstrated that LEN increased TNF-α and IL-8 inflammatory cytokines and insulin-like growth factor-1 (IGF-1) growth factor in both sensitive and resistant myeloma cells to LEN. CONCLUSION: Lenalidomide favours a uniform TNF-α and IL-8 inflammatory and IGF-1 secretory profile of myeloma cells, an observation that raises important questions for therapeutic approaches incorporating the agent.
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spelling pubmed-36585192014-05-14 Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma Maïga, S Gomez-Bougie, P Bonnaud, S Gratas, C Moreau, P Le Gouill, S Pellat-Deceunynck, C Amiot, M Br J Cancer Translational Therapeutics BACKGROUND: Lenalidomide is an active immunomodulatory and antiproliferative agent in multiple myeloma. However, the molecular mechanisms driving these activities are not yet fully elucidated. Therefore, we investigated the modulation of the cytokine/growth factor patterns of myeloma cells under LEN treatment. METHODS: Lenalidomide effect on myeloma cell proliferation was investigated in a myeloma cell line collection (n=23) by (3)H-thymidine incorporation. Modulation of the cytokine/growth factor patterns of myeloma cells under LEN treatment was analysed by real-time quantitative PCR. RESULTS: Lenalidomide inhibits the proliferation of two-thirds of myeloma cell lines independently of their genetic background. We demonstrated that LEN increased TNF-α and IL-8 inflammatory cytokines and insulin-like growth factor-1 (IGF-1) growth factor in both sensitive and resistant myeloma cells to LEN. CONCLUSION: Lenalidomide favours a uniform TNF-α and IL-8 inflammatory and IGF-1 secretory profile of myeloma cells, an observation that raises important questions for therapeutic approaches incorporating the agent. Nature Publishing Group 2013-05-14 2013-04-30 /pmc/articles/PMC3658519/ /pubmed/23632478 http://dx.doi.org/10.1038/bjc.2013.186 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Translational Therapeutics
Maïga, S
Gomez-Bougie, P
Bonnaud, S
Gratas, C
Moreau, P
Le Gouill, S
Pellat-Deceunynck, C
Amiot, M
Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma
title Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma
title_full Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma
title_fullStr Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma
title_full_unstemmed Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma
title_short Paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma
title_sort paradoxical effect of lenalidomide on cytokine/growth factor profiles in multiple myeloma
topic Translational Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658519/
https://www.ncbi.nlm.nih.gov/pubmed/23632478
http://dx.doi.org/10.1038/bjc.2013.186
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