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An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1

BACKGROUND: Bcl-2-like members have been found to be inherently overexpressed in many types of haematologic malignancies. The small-molecule S1 is a BH3 mimetic and a triple inhibitor of Bcl-2, Mcl-1 and Bcl-XL. METHODS: The lethal dose 50 (LD(50)) values of S1 in five leukaemic cell lines and 41 ne...

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Detalles Bibliográficos
Autores principales:	Zhang, Z, Liu, Y, Song, T, Xue, Z, Shen, X, Liang, F, Zhao, Y, Li, Z, Sheng, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658527/ https://www.ncbi.nlm.nih.gov/pubmed/23558901 http://dx.doi.org/10.1038/bjc.2013.152

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