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Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
Schizophrenia has been associated with a deficit of the prefrontal cortex, which is involved in attention, executive processes, and working memory. The Trail Making Test (TMT) is administered in two parts, TMT-A and TMT-B. It is suggested that the difference in performance between part A and part B...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658532/ https://www.ncbi.nlm.nih.gov/pubmed/23696704 http://dx.doi.org/10.2147/NDT.S43137 |
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author | Fujiki, Ryo Morita, Kiichiro Sato, Mamoru Kamada, Yuji Kato, Yusuke Inoue, Masayuki Shoji, Yoshihisa Uchimura, Naohisa |
author_facet | Fujiki, Ryo Morita, Kiichiro Sato, Mamoru Kamada, Yuji Kato, Yusuke Inoue, Masayuki Shoji, Yoshihisa Uchimura, Naohisa |
author_sort | Fujiki, Ryo |
collection | PubMed |
description | Schizophrenia has been associated with a deficit of the prefrontal cortex, which is involved in attention, executive processes, and working memory. The Trail Making Test (TMT) is administered in two parts, TMT-A and TMT-B. It is suggested that the difference in performance between part A and part B reflects executive processes. In this study, we compared the characteristics of hemodynamic changes during TMT tasks between 14 outpatients with schizophrenia and 14 age- and gender-matched healthy control subjects. Using multichannel near-infrared spectroscopy, we measured relative changes in oxygenated hemoglobin concentration, which reflects brain activity of the prefrontal cortex during this task. In both tasks, patients showed significantly smaller activation than controls and, in an assessment of executive functions, a subtraction of oxygenated hemoglobin (oxy-Hb) changes during TMT-A from those of TMT-B showed a decrease in cerebral lateralization and hypoactivity in patients. There was a significant negative correlation between oxy-Hb changes and the severity of psychiatric symptoms. These findings may characterize disease-related features, suggesting the usefulness of oxy-Hb change measurement during TMT tasks for assessing functional outcomes in schizophrenic patients. |
format | Online Article Text |
id | pubmed-3658532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36585322013-05-21 Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia Fujiki, Ryo Morita, Kiichiro Sato, Mamoru Kamada, Yuji Kato, Yusuke Inoue, Masayuki Shoji, Yoshihisa Uchimura, Naohisa Neuropsychiatr Dis Treat Original Research Schizophrenia has been associated with a deficit of the prefrontal cortex, which is involved in attention, executive processes, and working memory. The Trail Making Test (TMT) is administered in two parts, TMT-A and TMT-B. It is suggested that the difference in performance between part A and part B reflects executive processes. In this study, we compared the characteristics of hemodynamic changes during TMT tasks between 14 outpatients with schizophrenia and 14 age- and gender-matched healthy control subjects. Using multichannel near-infrared spectroscopy, we measured relative changes in oxygenated hemoglobin concentration, which reflects brain activity of the prefrontal cortex during this task. In both tasks, patients showed significantly smaller activation than controls and, in an assessment of executive functions, a subtraction of oxygenated hemoglobin (oxy-Hb) changes during TMT-A from those of TMT-B showed a decrease in cerebral lateralization and hypoactivity in patients. There was a significant negative correlation between oxy-Hb changes and the severity of psychiatric symptoms. These findings may characterize disease-related features, suggesting the usefulness of oxy-Hb change measurement during TMT tasks for assessing functional outcomes in schizophrenic patients. Dove Medical Press 2013 2013-05-16 /pmc/articles/PMC3658532/ /pubmed/23696704 http://dx.doi.org/10.2147/NDT.S43137 Text en © 2013 Fujiki et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Fujiki, Ryo Morita, Kiichiro Sato, Mamoru Kamada, Yuji Kato, Yusuke Inoue, Masayuki Shoji, Yoshihisa Uchimura, Naohisa Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia |
title | Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia |
title_full | Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia |
title_fullStr | Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia |
title_full_unstemmed | Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia |
title_short | Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia |
title_sort | reduced prefrontal cortex activation using the trail making test in schizophrenia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658532/ https://www.ncbi.nlm.nih.gov/pubmed/23696704 http://dx.doi.org/10.2147/NDT.S43137 |
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