Interleukin-12 prevents colorectal cancer liver metastases in mice

Interleukin (IL)-12 has emerged to be a prospective molecule for antitumor therapies with many types of cancers. Here we examine the effect of IL-12 treatment in preventing the colorectal cancer liver metastasis in a mice model. At different doses, we found that IL-12 treatment decreased the formati...

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Detalles Bibliográficos
Autores principales: Shen, Fei, Li, Jiang-Lin, Cai, Weng-Song, Zhu, Guang-Hui, Gu, Wei-Li, Jia, Lin, Xu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658535/
https://www.ncbi.nlm.nih.gov/pubmed/23696707
http://dx.doi.org/10.2147/OTT.S44161
Descripción
Sumario:Interleukin (IL)-12 has emerged to be a prospective molecule for antitumor therapies with many types of cancers. Here we examine the effect of IL-12 treatment in preventing the colorectal cancer liver metastasis in a mice model. At different doses, we found that IL-12 treatment decreased the formation of liver metastasis sites and the percentage of metastasis volume in the liver. Additionally, this treatment leads to improved survival function of mice after tumor cell transplantation. We believe that IL-12 based therapy provided a novel treatment to colorectal cancer patients suffering from liver metastasis.

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