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Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats
S-metolachlor is a chloroacetanilide herbicide widely used in the agriculture to control weeds and was demonstrated that it increases the activity of the aromatase enzyme in cell cultures, which may culminate as endocrine disruption action in vivo. To investigate this hypothesis, prepubertal Wistar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658572/ https://www.ncbi.nlm.nih.gov/pubmed/23724293 http://dx.doi.org/10.5402/2012/130846 |
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author | Mathias, Francielle Tatiane Romano, Renata Marino Sleiman, Hanan Kaled de Oliveira, Claudio Alvarenga Romano, Marco Aurelio |
author_facet | Mathias, Francielle Tatiane Romano, Renata Marino Sleiman, Hanan Kaled de Oliveira, Claudio Alvarenga Romano, Marco Aurelio |
author_sort | Mathias, Francielle Tatiane |
collection | PubMed |
description | S-metolachlor is a chloroacetanilide herbicide widely used in the agriculture to control weeds and was demonstrated that it increases the activity of the aromatase enzyme in cell cultures, which may culminate as endocrine disruption action in vivo. To investigate this hypothesis, prepubertal Wistar male rats were exposed to metolachlor (5 or 50 mg/kg/day, NOEL for reproductive toxicity: 23.5–26.0 mg/kg/day) from PND23 (postnatal day) to PND53. During this period, the growth of the animals and the age and weight at puberty were recorded. In PND53, tissues were collected and the analysis of LH, FSH, testosterone, dihydrotestosterone (DHT), estradiol serum concentrations, morphometric evaluation of the seminiferous epithelium, and weight of the testes and the seminal vesicle (undrained and drained) was performed (Statistical difference: P < 0.05). Metolachlor caused an increase in serum concentrations of testosterone, estradiol, and FSH and a reduction in DHT but did not alter the LH. There were also observed a higher amount of fluid in the seminal vesicles, precocious puberty, and changes in morphology of the seminiferous epithelium of treated animals. We demonstrated in this paper that prepubertal exposure to S-metolachlor caused changes in reproductive endocrinology of male rats. |
format | Online Article Text |
id | pubmed-3658572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-36585722013-05-30 Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats Mathias, Francielle Tatiane Romano, Renata Marino Sleiman, Hanan Kaled de Oliveira, Claudio Alvarenga Romano, Marco Aurelio ISRN Toxicol Research Article S-metolachlor is a chloroacetanilide herbicide widely used in the agriculture to control weeds and was demonstrated that it increases the activity of the aromatase enzyme in cell cultures, which may culminate as endocrine disruption action in vivo. To investigate this hypothesis, prepubertal Wistar male rats were exposed to metolachlor (5 or 50 mg/kg/day, NOEL for reproductive toxicity: 23.5–26.0 mg/kg/day) from PND23 (postnatal day) to PND53. During this period, the growth of the animals and the age and weight at puberty were recorded. In PND53, tissues were collected and the analysis of LH, FSH, testosterone, dihydrotestosterone (DHT), estradiol serum concentrations, morphometric evaluation of the seminiferous epithelium, and weight of the testes and the seminal vesicle (undrained and drained) was performed (Statistical difference: P < 0.05). Metolachlor caused an increase in serum concentrations of testosterone, estradiol, and FSH and a reduction in DHT but did not alter the LH. There were also observed a higher amount of fluid in the seminal vesicles, precocious puberty, and changes in morphology of the seminiferous epithelium of treated animals. We demonstrated in this paper that prepubertal exposure to S-metolachlor caused changes in reproductive endocrinology of male rats. International Scholarly Research Network 2012-04-18 /pmc/articles/PMC3658572/ /pubmed/23724293 http://dx.doi.org/10.5402/2012/130846 Text en Copyright © 2012 Francielle Tatiane Mathias et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mathias, Francielle Tatiane Romano, Renata Marino Sleiman, Hanan Kaled de Oliveira, Claudio Alvarenga Romano, Marco Aurelio Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats |
title | Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats |
title_full | Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats |
title_fullStr | Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats |
title_full_unstemmed | Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats |
title_short | Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats |
title_sort | herbicide metolachlor causes changes in reproductive endocrinology of male wistar rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658572/ https://www.ncbi.nlm.nih.gov/pubmed/23724293 http://dx.doi.org/10.5402/2012/130846 |
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