Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability

Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S. aureus (MRSA) as well as gram-negative pathogens. Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory con...

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Detalles Bibliográficos
Autores principales: Citron, Diane M., Warren, Yumi A., Tyrrell, Kerin L., Goldstein, Ellie J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658583/
https://www.ncbi.nlm.nih.gov/pubmed/23724310
http://dx.doi.org/10.5402/2011/787290
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author Citron, Diane M.
Warren, Yumi A.
Tyrrell, Kerin L.
Goldstein, Ellie J. C.
author_facet Citron, Diane M.
Warren, Yumi A.
Tyrrell, Kerin L.
Goldstein, Ellie J. C.
author_sort Citron, Diane M.
collection PubMed
description Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S. aureus (MRSA) as well as gram-negative pathogens. Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory concentrations (MICs) for E. coli, K. pneumoniae, M. catarrhalis, H. influenzae, and streptococci, while an inoculum of 10(6) CFU/mL raised MICs of some E. coli, K. pneumoniae, and M. catarrhalis strains.
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spelling pubmed-36585832013-05-30 Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability Citron, Diane M. Warren, Yumi A. Tyrrell, Kerin L. Goldstein, Ellie J. C. ISRN Microbiol Research Article Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S. aureus (MRSA) as well as gram-negative pathogens. Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory concentrations (MICs) for E. coli, K. pneumoniae, M. catarrhalis, H. influenzae, and streptococci, while an inoculum of 10(6) CFU/mL raised MICs of some E. coli, K. pneumoniae, and M. catarrhalis strains. International Scholarly Research Network 2011-11-17 /pmc/articles/PMC3658583/ /pubmed/23724310 http://dx.doi.org/10.5402/2011/787290 Text en Copyright © 2011 Diane M. Citron et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Citron, Diane M.
Warren, Yumi A.
Tyrrell, Kerin L.
Goldstein, Ellie J. C.
Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability
title Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability
title_full Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability
title_fullStr Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability
title_full_unstemmed Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability
title_short Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability
title_sort activity of ceftaroline against aerobic gram-positive and gram-negative pathogens: effect of test method variability
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658583/
https://www.ncbi.nlm.nih.gov/pubmed/23724310
http://dx.doi.org/10.5402/2011/787290
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