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Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation
Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and volu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658588/ https://www.ncbi.nlm.nih.gov/pubmed/23724232 http://dx.doi.org/10.5402/2011/818239 |
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author | Noviello, Maria de Lourdes Meirelles Batista, Nathália Vieira Dourado, Luana Pereira Antunes Cara, Denise Carmona |
author_facet | Noviello, Maria de Lourdes Meirelles Batista, Nathália Vieira Dourado, Luana Pereira Antunes Cara, Denise Carmona |
author_sort | Noviello, Maria de Lourdes Meirelles |
collection | PubMed |
description | Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA. We found a significant suppression of bronchial inflammation, with marked reduction of eosinophils. IL-4, CCL-2, and CCL-11 are not associated with elevation in IL-10 production or Foxp3 expression, with only minor digestive symptoms. |
format | Online Article Text |
id | pubmed-3658588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-36585882013-05-30 Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation Noviello, Maria de Lourdes Meirelles Batista, Nathália Vieira Dourado, Luana Pereira Antunes Cara, Denise Carmona ISRN Allergy Research Article Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA. We found a significant suppression of bronchial inflammation, with marked reduction of eosinophils. IL-4, CCL-2, and CCL-11 are not associated with elevation in IL-10 production or Foxp3 expression, with only minor digestive symptoms. International Scholarly Research Network 2011-12-01 /pmc/articles/PMC3658588/ /pubmed/23724232 http://dx.doi.org/10.5402/2011/818239 Text en Copyright © 2011 Maria de Lourdes Meirelles Noviello et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Noviello, Maria de Lourdes Meirelles Batista, Nathália Vieira Dourado, Luana Pereira Antunes Cara, Denise Carmona Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation |
title | Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation |
title_full | Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation |
title_fullStr | Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation |
title_full_unstemmed | Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation |
title_short | Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation |
title_sort | prolonged antigen ingestion by sensitized mice ameliorates airway inflammation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658588/ https://www.ncbi.nlm.nih.gov/pubmed/23724232 http://dx.doi.org/10.5402/2011/818239 |
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