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Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation

Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and volu...

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Autores principales: Noviello, Maria de Lourdes Meirelles, Batista, Nathália Vieira, Dourado, Luana Pereira Antunes, Cara, Denise Carmona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658588/
https://www.ncbi.nlm.nih.gov/pubmed/23724232
http://dx.doi.org/10.5402/2011/818239
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author Noviello, Maria de Lourdes Meirelles
Batista, Nathália Vieira
Dourado, Luana Pereira Antunes
Cara, Denise Carmona
author_facet Noviello, Maria de Lourdes Meirelles
Batista, Nathália Vieira
Dourado, Luana Pereira Antunes
Cara, Denise Carmona
author_sort Noviello, Maria de Lourdes Meirelles
collection PubMed
description Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA. We found a significant suppression of bronchial inflammation, with marked reduction of eosinophils. IL-4, CCL-2, and CCL-11 are not associated with elevation in IL-10 production or Foxp3 expression, with only minor digestive symptoms.
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spelling pubmed-36585882013-05-30 Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation Noviello, Maria de Lourdes Meirelles Batista, Nathália Vieira Dourado, Luana Pereira Antunes Cara, Denise Carmona ISRN Allergy Research Article Food allergy frequently precedes or coexists with respiratory allergy, and although restriction of contacts with the allergen is the elected clinical procedure, oral immunotherapy (OIT) has proven to be surprisingly efficient in clinical trials. We investigated whether prolonged restriction and voluntary exposure of previously sensitized (immunized) mice to ovalbumin (OVA) in the drinking water would alter subsequent responses to bronchial (aerosol) challenge with OVA. We found a significant suppression of bronchial inflammation, with marked reduction of eosinophils. IL-4, CCL-2, and CCL-11 are not associated with elevation in IL-10 production or Foxp3 expression, with only minor digestive symptoms. International Scholarly Research Network 2011-12-01 /pmc/articles/PMC3658588/ /pubmed/23724232 http://dx.doi.org/10.5402/2011/818239 Text en Copyright © 2011 Maria de Lourdes Meirelles Noviello et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Noviello, Maria de Lourdes Meirelles
Batista, Nathália Vieira
Dourado, Luana Pereira Antunes
Cara, Denise Carmona
Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation
title Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation
title_full Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation
title_fullStr Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation
title_full_unstemmed Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation
title_short Prolonged Antigen Ingestion by Sensitized Mice Ameliorates Airway Inflammation
title_sort prolonged antigen ingestion by sensitized mice ameliorates airway inflammation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658588/
https://www.ncbi.nlm.nih.gov/pubmed/23724232
http://dx.doi.org/10.5402/2011/818239
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