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Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids

Changes in diet can also have dramatic effects on the composition of gut microbiota. Commensal bacteria of the gastrointestinal tract are critical regulators of health and disease by protecting against pathogen encounter whilst also maintaining immune tolerance to certain allergens. Moreover, consum...

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Autores principales: Licciardi, Paul V., Ververis, Katherine, Karagiannis, Tom C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658706/
https://www.ncbi.nlm.nih.gov/pubmed/23724235
http://dx.doi.org/10.5402/2011/869647
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author Licciardi, Paul V.
Ververis, Katherine
Karagiannis, Tom C.
author_facet Licciardi, Paul V.
Ververis, Katherine
Karagiannis, Tom C.
author_sort Licciardi, Paul V.
collection PubMed
description Changes in diet can also have dramatic effects on the composition of gut microbiota. Commensal bacteria of the gastrointestinal tract are critical regulators of health and disease by protecting against pathogen encounter whilst also maintaining immune tolerance to certain allergens. Moreover, consumption of fibre and vegetables typical of a non-Western diet generates substantial quantities of short-chain fatty acids (SCFAs) which have potent anti-inflammatory properties. Dietary interventions such as probiotic supplementation have been investigated for their pleiotropic effects on microbiota composition and immune function. Probiotics may restore intestinal dysbiosis and improve clinical disease through elevated SCFA levels in the intestine. Although the precise mechanisms by which such dietary factors mediate these effects, SCFA metabolites such as butyrate also function as histone deacetylase inhibitors (HDACi), that can act on the epigenome through chromatin remodeling changes. The aim of this review is to provide an overview of HDAC enzymes and to discuss the biological effects of HDACi. Further, we discuss the important relationship between diet and the balance between health and disease and how novel dietary interventions such as probiotics could be alternative approach for the prevention and/or treatment of chronic inflammatory disease through modulation of the intestinal microbiome.
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spelling pubmed-36587062013-05-30 Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids Licciardi, Paul V. Ververis, Katherine Karagiannis, Tom C. ISRN Allergy Review Article Changes in diet can also have dramatic effects on the composition of gut microbiota. Commensal bacteria of the gastrointestinal tract are critical regulators of health and disease by protecting against pathogen encounter whilst also maintaining immune tolerance to certain allergens. Moreover, consumption of fibre and vegetables typical of a non-Western diet generates substantial quantities of short-chain fatty acids (SCFAs) which have potent anti-inflammatory properties. Dietary interventions such as probiotic supplementation have been investigated for their pleiotropic effects on microbiota composition and immune function. Probiotics may restore intestinal dysbiosis and improve clinical disease through elevated SCFA levels in the intestine. Although the precise mechanisms by which such dietary factors mediate these effects, SCFA metabolites such as butyrate also function as histone deacetylase inhibitors (HDACi), that can act on the epigenome through chromatin remodeling changes. The aim of this review is to provide an overview of HDAC enzymes and to discuss the biological effects of HDACi. Further, we discuss the important relationship between diet and the balance between health and disease and how novel dietary interventions such as probiotics could be alternative approach for the prevention and/or treatment of chronic inflammatory disease through modulation of the intestinal microbiome. International Scholarly Research Network 2011-12-26 /pmc/articles/PMC3658706/ /pubmed/23724235 http://dx.doi.org/10.5402/2011/869647 Text en Copyright © 2011 Paul V. Licciardi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Licciardi, Paul V.
Ververis, Katherine
Karagiannis, Tom C.
Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
title Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
title_full Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
title_fullStr Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
title_full_unstemmed Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
title_short Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids
title_sort histone deacetylase inhibition and dietary short-chain fatty acids
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658706/
https://www.ncbi.nlm.nih.gov/pubmed/23724235
http://dx.doi.org/10.5402/2011/869647
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