Cargando…

Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

The etiology of feline injection-site sarcomas remains obscure. Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats. However, the available evidence suggests that this is not the case with feline injection-site sarcomas. These tumors...

Descripción completa

Detalles Bibliográficos
Autor principal: Woodward, Kevin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658838/
https://www.ncbi.nlm.nih.gov/pubmed/23738095
http://dx.doi.org/10.5402/2011/210982
_version_ 1782270343872774144
author Woodward, Kevin N.
author_facet Woodward, Kevin N.
author_sort Woodward, Kevin N.
collection PubMed
description The etiology of feline injection-site sarcomas remains obscure. Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats. However, the available evidence suggests that this is not the case with feline injection-site sarcomas. These tumors have more in common with sarcomas noted in experimental studies with laboratory animals where foreign materials such as glass, plastics, and metal are the causal agent. Tumors arising with these agents are associated with chronic inflammation at the injection or implantation sites. Similar tumors have been observed, albeit infrequently, at microchip implantation sites, and these also are associated with chronic inflammation. It is suggested that injection-site sarcomas in cats may arise at the administration site as a result of chronic inflammation, possibly provoked by adjuvant materials, with subsequent DNA damage, cellular transformation, and clonal expansion. However, more fundamental research is required to elucidate the mechanisms involved.
format Online
Article
Text
id pubmed-3658838
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher International Scholarly Research Network
record_format MEDLINE/PubMed
spelling pubmed-36588382013-06-04 Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review Woodward, Kevin N. ISRN Vet Sci Review Article The etiology of feline injection-site sarcomas remains obscure. Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats. However, the available evidence suggests that this is not the case with feline injection-site sarcomas. These tumors have more in common with sarcomas noted in experimental studies with laboratory animals where foreign materials such as glass, plastics, and metal are the causal agent. Tumors arising with these agents are associated with chronic inflammation at the injection or implantation sites. Similar tumors have been observed, albeit infrequently, at microchip implantation sites, and these also are associated with chronic inflammation. It is suggested that injection-site sarcomas in cats may arise at the administration site as a result of chronic inflammation, possibly provoked by adjuvant materials, with subsequent DNA damage, cellular transformation, and clonal expansion. However, more fundamental research is required to elucidate the mechanisms involved. International Scholarly Research Network 2011-04-12 /pmc/articles/PMC3658838/ /pubmed/23738095 http://dx.doi.org/10.5402/2011/210982 Text en Copyright © 2011 Kevin N. Woodward. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Woodward, Kevin N.
Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review
title Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review
title_full Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review
title_fullStr Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review
title_full_unstemmed Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review
title_short Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review
title_sort origins of injection-site sarcomas in cats: the possible role of chronic inflammation—a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658838/
https://www.ncbi.nlm.nih.gov/pubmed/23738095
http://dx.doi.org/10.5402/2011/210982
work_keys_str_mv AT woodwardkevinn originsofinjectionsitesarcomasincatsthepossibleroleofchronicinflammationareview