Chimeric antigen receptor containing ICOS signaling domain mediates specific and efficient antitumor effect of T cells against EGFRvIII expressing glioma

BACKGROUND: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells appears to be a promising immunotherapeutic strategy. CAR combines the specificity of antibody and cytotoxicity of cytotoxic T lymphocytes, enhancing T cells’ ability to specifically target antigens and to effectively...

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Detalles Bibliográficos
Autores principales: Shen, Chan-Juan, Yang, Yu-Xiu, Han, Ethan Q, Cao, Na, Wang, Yun-Fei, Wang, Yi, Zhao, Ying-Ying, Zhao, Li-Ming, Cui, Jian, Gupta, Puja, Wong, Albert J, Han, Shuang-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658918/
https://www.ncbi.nlm.nih.gov/pubmed/23656794
http://dx.doi.org/10.1186/1756-8722-6-33

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