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Empirical Bayesian analysis of paired high-throughput sequencing data with a beta-binomial distribution

BACKGROUND: Pairing of samples arises naturally in many genomic experiments; for example, gene expression in tumour and normal tissue from the same patients. Methods for analysing high-throughput sequencing data from such experiments are required to identify differential expression, both within pair...

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Detalles Bibliográficos
Autores principales: Hardcastle, Thomas J, Kelly, Krystyna A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658937/
https://www.ncbi.nlm.nih.gov/pubmed/23617841
http://dx.doi.org/10.1186/1471-2105-14-135