Detection of JC Virus-Specific Immune Responses in a Novel Humanized Mouse Model

Progressive Multifocal Leukoencephalopathy (PML) is an often fatal disease caused by the reactivation of the JC virus (JCV). Better understanding of viral-host interactions has been hampered by the lack of an animal model. Engrafting NOD/SCID/IL-2-Rg (null) mice with human lymphocytes and thymus, we...

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Detalles Bibliográficos
Autores principales: Tan, Chen Sabrina, Broge, Thomas A., Seung, Edward, Vrbanac, Vlad, Viscidi, Raphael, Gordon, Jennifer, Tager, Andrew M., Koralnik, Igor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658964/
https://www.ncbi.nlm.nih.gov/pubmed/23700470
http://dx.doi.org/10.1371/journal.pone.0064313

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