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Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice

AIMS: Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(−/−)) deficiency on leukocyte subsets releva...

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Detalles Bibliográficos
Autores principales:	Bot, Martine, Van Veldhoven, Paul P., de Jager, Saskia C. A., Johnson, Jason, Nijstad, Niels, Van Santbrink, Peter J., Westra, Marijke M., Van Der Hoeven, Gerd, Gijbels, Marion J., Müller-Tidow, Carsten, Varga, Georg, Tietge, Uwe J. F., Kuiper, Johan, Van Berkel, Theo J. C., Nofer, Jerzy-Roch, Bot, Ilze, Biessen, Erik A. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659045/ https://www.ncbi.nlm.nih.gov/pubmed/23700419 http://dx.doi.org/10.1371/journal.pone.0063360

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