Activation of TrkB with TAM-163 Results in Opposite Effects on Body Weight in Rodents and Non-Human Primates

Strong genetic data link the Tyrosine kinase receptor B (TrkB) and its major endogenous ligand brain-derived neurotrophic factor (BDNF) to the regulation of energy homeostasis, with loss-of-function mutations in either gene causing severe obesity in both mice and humans. It has previously been repor...

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Detalles Bibliográficos
Autores principales: Perreault, Mylène, Feng, Guo, Will, Sarah, Gareski, Tiffany, Kubasiak, David, Marquette, Kimberly, Vugmeyster, Yulia, Unger, Thaddeus J., Jones, Juli, Qadri, Ariful, Hahm, Seung, Sun, Ying, Rohde, Cynthia M., Zwijnenberg, Raphael, Paulsen, Janet, Gimeno, Ruth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659094/
https://www.ncbi.nlm.nih.gov/pubmed/23700410
http://dx.doi.org/10.1371/journal.pone.0062616

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