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Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease
Loss of huntingtin-mediated BDNF gene transcription has been shown to occur in HD and thus contribute to the degeneration of the striatum. Several studies have indicated that an increase in BDNF levels is associated with neuroprotection and amelioration of neurological signs in animal models of HD....
Autores principales: | Giampà, Carmela, Montagna, Elena, Dato, Clemente, Melone, Mariarosa A. B., Bernardi, Giorgio, Fusco, Francesca Romana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659095/ https://www.ncbi.nlm.nih.gov/pubmed/23700454 http://dx.doi.org/10.1371/journal.pone.0064037 |
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