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Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease

Loss of huntingtin-mediated BDNF gene transcription has been shown to occur in HD and thus contribute to the degeneration of the striatum. Several studies have indicated that an increase in BDNF levels is associated with neuroprotection and amelioration of neurological signs in animal models of HD....

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Detalles Bibliográficos
Autores principales:	Giampà, Carmela, Montagna, Elena, Dato, Clemente, Melone, Mariarosa A. B., Bernardi, Giorgio, Fusco, Francesca Romana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659095/ https://www.ncbi.nlm.nih.gov/pubmed/23700454 http://dx.doi.org/10.1371/journal.pone.0064037

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