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A Herpes Simplex Virus-Derived Replicative Vector Expressing LIF Limits Experimental Demyelinating Disease and Modulates Autoimmunity

Herpes simplex virus type 1 (HSV-1) has properties that can be exploited for the development of gene therapy vectors. The neurotropism of HSV enables delivery of therapeutic genes to the nervous system. Using a bacterial artificial chromosome (BAC), we constructed an HSV-1(17(+))-based replicative v...

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Detalles Bibliográficos
Autores principales:	Nygårdas, Michaela, Paavilainen, Henrik, Müther, Nadine, Nagel, Claus-Henning, Röyttä, Matias, Sodeik, Beate, Hukkanen, Veijo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659099/ https://www.ncbi.nlm.nih.gov/pubmed/23700462 http://dx.doi.org/10.1371/journal.pone.0064200

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