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Quantitative Label-Free Proteomics for Discovery of Biomarkers in Cerebrospinal Fluid: Assessment of Technical and Inter-Individual Variation

BACKGROUND: Biomarkers are required for pre-symptomatic diagnosis, treatment, and monitoring of neurodegenerative diseases such as Alzheimer's disease. Cerebrospinal fluid (CSF) is a favored source because its proteome reflects the composition of the brain. Ideal biomarkers have low technical a...

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Detalles Bibliográficos
Autores principales:	Perrin, Richard J., Payton, Jacqueline E., Malone, James P., Gilmore, Petra, Davis, Alan E., Xiong, Chengjie, Fagan, Anne M., Townsend, R. Reid, Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659127/ https://www.ncbi.nlm.nih.gov/pubmed/23700471 http://dx.doi.org/10.1371/journal.pone.0064314

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