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RNA toxicity in polyglutamine disorders: concepts, models, and progress of research
In Huntington's disease and other polyglutamine (polyQ) disorders, mutant proteins containing a long polyQ stretch are well documented as the trigger of numerous aberrant cellular processes that primarily lead to degeneration and, ultimately, the death of neuronal cells. However, mutant transcr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer-Verlag
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659269/ https://www.ncbi.nlm.nih.gov/pubmed/23512265 http://dx.doi.org/10.1007/s00109-013-1016-2 |