Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity

Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities. Recent studies in mammals and zebrafish have implicated some of these splice isoforms in control of both cellular and body homeost...

Descripción completa

Detalles Bibliográficos
Autores principales: Blechman, Janna, Levkowitz, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659299/
https://www.ncbi.nlm.nih.gov/pubmed/23734144
http://dx.doi.org/10.3389/fendo.2013.00055
_version_ 1782270429253074944
author Blechman, Janna
Levkowitz, Gil
author_facet Blechman, Janna
Levkowitz, Gil
author_sort Blechman, Janna
collection PubMed
description Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities. Recent studies in mammals and zebrafish have implicated some of these splice isoforms in control of both cellular and body homeostasis. Here, we review the regulation of PAC1 splice variants and their underlying signal transduction and physiological processes in the nervous system.
format Online
Article
Text
id pubmed-3659299
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36592992013-06-03 Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity Blechman, Janna Levkowitz, Gil Front Endocrinol (Lausanne) Endocrinology Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities. Recent studies in mammals and zebrafish have implicated some of these splice isoforms in control of both cellular and body homeostasis. Here, we review the regulation of PAC1 splice variants and their underlying signal transduction and physiological processes in the nervous system. Frontiers Media S.A. 2013-05-21 /pmc/articles/PMC3659299/ /pubmed/23734144 http://dx.doi.org/10.3389/fendo.2013.00055 Text en Copyright © 2013 Blechman and Levkowitz. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Endocrinology
Blechman, Janna
Levkowitz, Gil
Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity
title Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity
title_full Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity
title_fullStr Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity
title_full_unstemmed Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity
title_short Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity
title_sort alternative splicing of the pituitary adenylate cyclase-activating polypeptide receptor pac1: mechanisms of fine tuning of brain activity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659299/
https://www.ncbi.nlm.nih.gov/pubmed/23734144
http://dx.doi.org/10.3389/fendo.2013.00055
work_keys_str_mv AT blechmanjanna alternativesplicingofthepituitaryadenylatecyclaseactivatingpolypeptidereceptorpac1mechanismsoffinetuningofbrainactivity
AT levkowitzgil alternativesplicingofthepituitaryadenylatecyclaseactivatingpolypeptidereceptorpac1mechanismsoffinetuningofbrainactivity

Ejemplares similares