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Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo

The potent inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of several chronic inflammatory conditions, including periodontitis. The inducible enzyme microsomal prostaglandin E synthase-1 (mPGES-1), catalyzing the terminal step of PGE(2) biosynthesis, is an attract...

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Detalles Bibliográficos
Autores principales:	Kats, Anna, Båge, Tove, Georgsson, Pierre, Jönsson, Jörgen, Quezada, Hernán Concha, Gustafsson, Anders, Jansson, Leif, Lindberg, Claes, Näsström, Karin, Yucel-Lindberg, Tülay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2013
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659347/ https://www.ncbi.nlm.nih.gov/pubmed/23447581 http://dx.doi.org/10.1096/fj.12-214445

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