Cargando…

Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats

Coronary heart disease (CHD) is one of the highest mortality diseases in the world. Traditional Chinese medicine compound Danshen dripping pills (CDDPs) have currently made a great achievement in treating CHD. However, the therapeutic mechanism of CDDP is often poorly interpreted. In this study, a G...

Descripción completa

Detalles Bibliográficos
Autores principales: Xin, Xue, Zou, Haimiao, Zheng, Ningning, Xu, Xinchun, Liu, Yinmin, Wang, Xiaoxian, Wu, Hongbing, Lu, Lina, Su, Jing, Qiu, Mingfeng, Wang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659432/
https://www.ncbi.nlm.nih.gov/pubmed/23737844
http://dx.doi.org/10.1155/2013/718305
_version_ 1782270440643756032
author Xin, Xue
Zou, Haimiao
Zheng, Ningning
Xu, Xinchun
Liu, Yinmin
Wang, Xiaoxian
Wu, Hongbing
Lu, Lina
Su, Jing
Qiu, Mingfeng
Wang, Xiaoyan
author_facet Xin, Xue
Zou, Haimiao
Zheng, Ningning
Xu, Xinchun
Liu, Yinmin
Wang, Xiaoxian
Wu, Hongbing
Lu, Lina
Su, Jing
Qiu, Mingfeng
Wang, Xiaoyan
author_sort Xin, Xue
collection PubMed
description Coronary heart disease (CHD) is one of the highest mortality diseases in the world. Traditional Chinese medicine compound Danshen dripping pills (CDDPs) have currently made a great achievement in treating CHD. However, the therapeutic mechanism of CDDP is often poorly interpreted. In this study, a GC-MS-based metabonomic study was conducted to assess the holistic efficacy of CDDP for myocardial infarction in male Sprague-Dawley rats, which were divided into the control group, the sham group, the model group, the control + CDDP group, and the model + CDDP, with CDDP at a dose of 107 mg/kg·d (equal to 1.8 mL/kg·d). The metabonomic findings demonstrated great differences of metabolic pattern among sham, model, and the model + CDDP in the orthogonal partial least squares discriminant analysis (OPLS-DA) models, which coordinated well with the assessment of plasma biochemistry and histopathological assay. Differentially expressed metabolites suggested that energy metabolism, glycolysis, and lipid metabolism might be disrupted by myocardial infarction. Both the potential metabolic biomarkers and the biochemical histopathological indices were regulated effectively by CDDP.
format Online
Article
Text
id pubmed-3659432
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36594322013-06-04 Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats Xin, Xue Zou, Haimiao Zheng, Ningning Xu, Xinchun Liu, Yinmin Wang, Xiaoxian Wu, Hongbing Lu, Lina Su, Jing Qiu, Mingfeng Wang, Xiaoyan Evid Based Complement Alternat Med Research Article Coronary heart disease (CHD) is one of the highest mortality diseases in the world. Traditional Chinese medicine compound Danshen dripping pills (CDDPs) have currently made a great achievement in treating CHD. However, the therapeutic mechanism of CDDP is often poorly interpreted. In this study, a GC-MS-based metabonomic study was conducted to assess the holistic efficacy of CDDP for myocardial infarction in male Sprague-Dawley rats, which were divided into the control group, the sham group, the model group, the control + CDDP group, and the model + CDDP, with CDDP at a dose of 107 mg/kg·d (equal to 1.8 mL/kg·d). The metabonomic findings demonstrated great differences of metabolic pattern among sham, model, and the model + CDDP in the orthogonal partial least squares discriminant analysis (OPLS-DA) models, which coordinated well with the assessment of plasma biochemistry and histopathological assay. Differentially expressed metabolites suggested that energy metabolism, glycolysis, and lipid metabolism might be disrupted by myocardial infarction. Both the potential metabolic biomarkers and the biochemical histopathological indices were regulated effectively by CDDP. Hindawi Publishing Corporation 2013 2013-05-02 /pmc/articles/PMC3659432/ /pubmed/23737844 http://dx.doi.org/10.1155/2013/718305 Text en Copyright © 2013 Xue Xin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xin, Xue
Zou, Haimiao
Zheng, Ningning
Xu, Xinchun
Liu, Yinmin
Wang, Xiaoxian
Wu, Hongbing
Lu, Lina
Su, Jing
Qiu, Mingfeng
Wang, Xiaoyan
Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
title Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
title_full Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
title_fullStr Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
title_full_unstemmed Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
title_short Metabonomic Strategy to the Evaluation of Chinese Medicine Compound Danshen Dripping Pills Interfering Myocardial Ischemia in Rats
title_sort metabonomic strategy to the evaluation of chinese medicine compound danshen dripping pills interfering myocardial ischemia in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659432/
https://www.ncbi.nlm.nih.gov/pubmed/23737844
http://dx.doi.org/10.1155/2013/718305
work_keys_str_mv AT xinxue metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT zouhaimiao metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT zhengningning metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT xuxinchun metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT liuyinmin metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT wangxiaoxian metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT wuhongbing metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT lulina metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT sujing metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT qiumingfeng metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats
AT wangxiaoyan metabonomicstrategytotheevaluationofchinesemedicinecompounddanshendrippingpillsinterferingmyocardialischemiainrats