Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?

Nanoparticle albumin bound paclitaxel (nab-paclitaxel) represents the first nanotechnology-based drug in cancer treatment. We discuss the development of this innovative compound and report the recent changing-practice results in breast and pancreatic cancer. A ground-breaking finding is the demonstr...

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Autores principales: Cucinotto, Iole, Fiorillo, Lucia, Gualtieri, Simona, Arbitrio, Mariamena, Ciliberto, Domenico, Staropoli, Nicoletta, Grimaldi, Anna, Luce, Amalia, Tassone, Pierfrancesco, Caraglia, Michele, Tagliaferri, Pierosandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659516/
https://www.ncbi.nlm.nih.gov/pubmed/23738077
http://dx.doi.org/10.1155/2013/905091
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author Cucinotto, Iole
Fiorillo, Lucia
Gualtieri, Simona
Arbitrio, Mariamena
Ciliberto, Domenico
Staropoli, Nicoletta
Grimaldi, Anna
Luce, Amalia
Tassone, Pierfrancesco
Caraglia, Michele
Tagliaferri, Pierosandro
author_facet Cucinotto, Iole
Fiorillo, Lucia
Gualtieri, Simona
Arbitrio, Mariamena
Ciliberto, Domenico
Staropoli, Nicoletta
Grimaldi, Anna
Luce, Amalia
Tassone, Pierfrancesco
Caraglia, Michele
Tagliaferri, Pierosandro
author_sort Cucinotto, Iole
collection PubMed
description Nanoparticle albumin bound paclitaxel (nab-paclitaxel) represents the first nanotechnology-based drug in cancer treatment. We discuss the development of this innovative compound and report the recent changing-practice results in breast and pancreatic cancer. A ground-breaking finding is the demonstration that nab-paclitaxel can not only enhance the activity and reduce the toxicity of chromophore-diluted compound, but also exert activity in diseases considered refractory to taxane-based treatment. This is the first clinical demonstration of major activity of nanotechnologically modified drugs in the treatment of human neoplasms.
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spelling pubmed-36595162013-06-04 Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time? Cucinotto, Iole Fiorillo, Lucia Gualtieri, Simona Arbitrio, Mariamena Ciliberto, Domenico Staropoli, Nicoletta Grimaldi, Anna Luce, Amalia Tassone, Pierfrancesco Caraglia, Michele Tagliaferri, Pierosandro J Drug Deliv Review Article Nanoparticle albumin bound paclitaxel (nab-paclitaxel) represents the first nanotechnology-based drug in cancer treatment. We discuss the development of this innovative compound and report the recent changing-practice results in breast and pancreatic cancer. A ground-breaking finding is the demonstration that nab-paclitaxel can not only enhance the activity and reduce the toxicity of chromophore-diluted compound, but also exert activity in diseases considered refractory to taxane-based treatment. This is the first clinical demonstration of major activity of nanotechnologically modified drugs in the treatment of human neoplasms. Hindawi Publishing Corporation 2013 2013-05-02 /pmc/articles/PMC3659516/ /pubmed/23738077 http://dx.doi.org/10.1155/2013/905091 Text en Copyright © 2013 Iole Cucinotto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cucinotto, Iole
Fiorillo, Lucia
Gualtieri, Simona
Arbitrio, Mariamena
Ciliberto, Domenico
Staropoli, Nicoletta
Grimaldi, Anna
Luce, Amalia
Tassone, Pierfrancesco
Caraglia, Michele
Tagliaferri, Pierosandro
Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?
title Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?
title_full Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?
title_fullStr Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?
title_full_unstemmed Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?
title_short Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?
title_sort nanoparticle albumin bound paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659516/
https://www.ncbi.nlm.nih.gov/pubmed/23738077
http://dx.doi.org/10.1155/2013/905091
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