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Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract
To obtain microorganisms for the microbial conversion of ginsenosides in red ginseng extract (RGE), mushroom mycelia were used for the fermentation of RGE. After fermentation, total sugar contents and polyohenol contents of the RGEs fermented with various mushrooms were not a significant increase be...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Ginseng
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659518/ https://www.ncbi.nlm.nih.gov/pubmed/23717066 http://dx.doi.org/10.5142/jgr.2011.35.2.235 |
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author | Bae, Song Hwan Lee, Hyun-Sun Kim, Mi-Ryung Kim, Sun Young Kim, Jin-Man Suh, Hyung Joo |
author_facet | Bae, Song Hwan Lee, Hyun-Sun Kim, Mi-Ryung Kim, Sun Young Kim, Jin-Man Suh, Hyung Joo |
author_sort | Bae, Song Hwan |
collection | PubMed |
description | To obtain microorganisms for the microbial conversion of ginsenosides in red ginseng extract (RGE), mushroom mycelia were used for the fermentation of RGE. After fermentation, total sugar contents and polyohenol contents of the RGEs fermented with various mushrooms were not a significant increase between RGE and the ferments. But uronic acid content was relatively higher in the fermented RGEs cultured with Lentus edodes (2155.6 μg/mL), Phelllinus linteus (1690.9 μg/mL) and Inonotus obliquus 26137 and 26147 (1549.5 and 1670.7 μg/mL) compared to the RGE (1307.1 μg/mL). The RGEs fermented by Ph. linteus, Cordyceps militaris, and Grifola frondosa showed particularly high levels of total ginsenosides (20018.1, 17501.6, and 16267.0 μg/mL, respectively). The ferments with C. militaris (6974.2 μg/mL), Ph. linteus (9109.2 μg/mL), and G. frondosa (7023.0 μg/mL) also showed high levels of metabolites (sum of compound K, Rh(1), Rg(5), Rk(1), Rg(3), and Rg(2)) compared to RGE (3615.9 μg/mL). Among four different RGE concentrations examined, a 20 brix concentration of RGE was favorable for the fermentation of Ph. linteus. Maximum biotransformation of ginsneoside metabolites (9395.5 μg/mL) was obtained after 5 days fermentation with Ph. linteus. Maximum mycelial growth of 2.6 mg/mL was achieved at 9 days, in which growth was not significantly different during 5 to 9 days fermentation. During fermentation of RGE by Ph. linteus in a 7 L fermenter, Rg(3), Rg(5), and Rk(1) contents showed maximum concentrations after 5 days similar to flask fermentation. These results confirm that fermentation with Ph. linteus is very useful for preparing minor ginsenoside metabolites while being safe for foods. |
format | Online Article Text |
id | pubmed-3659518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Society of Ginseng |
record_format | MEDLINE/PubMed |
spelling | pubmed-36595182013-05-28 Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract Bae, Song Hwan Lee, Hyun-Sun Kim, Mi-Ryung Kim, Sun Young Kim, Jin-Man Suh, Hyung Joo J Ginseng Res Articles To obtain microorganisms for the microbial conversion of ginsenosides in red ginseng extract (RGE), mushroom mycelia were used for the fermentation of RGE. After fermentation, total sugar contents and polyohenol contents of the RGEs fermented with various mushrooms were not a significant increase between RGE and the ferments. But uronic acid content was relatively higher in the fermented RGEs cultured with Lentus edodes (2155.6 μg/mL), Phelllinus linteus (1690.9 μg/mL) and Inonotus obliquus 26137 and 26147 (1549.5 and 1670.7 μg/mL) compared to the RGE (1307.1 μg/mL). The RGEs fermented by Ph. linteus, Cordyceps militaris, and Grifola frondosa showed particularly high levels of total ginsenosides (20018.1, 17501.6, and 16267.0 μg/mL, respectively). The ferments with C. militaris (6974.2 μg/mL), Ph. linteus (9109.2 μg/mL), and G. frondosa (7023.0 μg/mL) also showed high levels of metabolites (sum of compound K, Rh(1), Rg(5), Rk(1), Rg(3), and Rg(2)) compared to RGE (3615.9 μg/mL). Among four different RGE concentrations examined, a 20 brix concentration of RGE was favorable for the fermentation of Ph. linteus. Maximum biotransformation of ginsneoside metabolites (9395.5 μg/mL) was obtained after 5 days fermentation with Ph. linteus. Maximum mycelial growth of 2.6 mg/mL was achieved at 9 days, in which growth was not significantly different during 5 to 9 days fermentation. During fermentation of RGE by Ph. linteus in a 7 L fermenter, Rg(3), Rg(5), and Rk(1) contents showed maximum concentrations after 5 days similar to flask fermentation. These results confirm that fermentation with Ph. linteus is very useful for preparing minor ginsenoside metabolites while being safe for foods. The Korean Society of Ginseng 2011-06 /pmc/articles/PMC3659518/ /pubmed/23717066 http://dx.doi.org/10.5142/jgr.2011.35.2.235 Text en Copyright ©2011, The Korean Society of Ginseng http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Bae, Song Hwan Lee, Hyun-Sun Kim, Mi-Ryung Kim, Sun Young Kim, Jin-Man Suh, Hyung Joo Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract |
title | Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract |
title_full | Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract |
title_fullStr | Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract |
title_full_unstemmed | Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract |
title_short | Changes of Ginsenoside Content by Mushroom Mycelial Fermentation in Red Ginseng Extract |
title_sort | changes of ginsenoside content by mushroom mycelial fermentation in red ginseng extract |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659518/ https://www.ncbi.nlm.nih.gov/pubmed/23717066 http://dx.doi.org/10.5142/jgr.2011.35.2.235 |
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