Therapeutic Effect of Korean Red Ginseng Extract on Infertility Caused by Polycystic Ovaries

Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in a...

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Detalles Bibliográficos
Autores principales: Jung, Ji-Hun, Park, Hyun Tae, Kim, Tak, Jeong, Moon Jin, Lim, Sung Chul, Nah, Seung Yeol, Cho, Ik-Hyun, Park, Soo Hyun, Kang, Seong Soo, Moon, Chang Jong, Kim, Jong Choon, Kim, Sung Ho, Bae, Chun Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Ginseng 2011
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659527/
https://www.ncbi.nlm.nih.gov/pubmed/23717068
http://dx.doi.org/10.5142/jgr.2011.35.2.250
Descripción
Sumario:Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 mg/kg body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.

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