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Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans

In the previous report, we have demonstrated that ginsenoside Rc, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside Rh(1) an...

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Autores principales: Lee, Joon-Hee, Ahn, Ji-Yun, Shin, Tae-Joon, Choi, Sun-Hye, Lee, Byung-Hwan, Hwang, Sung-Hee, Kang, Jiyeon, Kim, Hyeon-Joong, Park, Chan-Woo, Nah, Seung-Yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Ginseng 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659541/
https://www.ncbi.nlm.nih.gov/pubmed/23717083
http://dx.doi.org/10.5142/jgr.2011.35.3.375
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author Lee, Joon-Hee
Ahn, Ji-Yun
Shin, Tae-Joon
Choi, Sun-Hye
Lee, Byung-Hwan
Hwang, Sung-Hee
Kang, Jiyeon
Kim, Hyeon-Joong
Park, Chan-Woo
Nah, Seung-Yeol
author_facet Lee, Joon-Hee
Ahn, Ji-Yun
Shin, Tae-Joon
Choi, Sun-Hye
Lee, Byung-Hwan
Hwang, Sung-Hee
Kang, Jiyeon
Kim, Hyeon-Joong
Park, Chan-Woo
Nah, Seung-Yeol
author_sort Lee, Joon-Hee
collection PubMed
description In the previous report, we have demonstrated that ginsenoside Rc, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside Rh(1) and Rh(2), ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) and ginsenoside epimers such as 20(R)- and 20(S)-ginsenoside Rg(3) in cholesterol-deprived medium. We found that ginsenoside Rh(1) almost restored normal growth of worms in cholesterol-deprived medium in F1 generation. However, supplement of ginsenoside Rh(2) caused a suppression of worm growths in cholesterol-deprived medium. In addition, CK and PPD also slightly restored normal growth of worms in cholesterol-deprived medium but PPT not. In experiments using ginsenoside epimers, supplement of 20(S)- but not 20(R)-ginsenoside Rg(3) in cholesterol-deprived medium also almost restored worm growth. These results indicate that the absence or presence of carbohydrate component at backbone of ginsenoside, the number of carbohydrate attached at carbon-3, and the position of hydroxyl group at carbon-20 of ginsenoside might plays important roles in restoration of worm growth in cholesterol-deprived medium.
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spelling pubmed-36595412013-05-28 Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans Lee, Joon-Hee Ahn, Ji-Yun Shin, Tae-Joon Choi, Sun-Hye Lee, Byung-Hwan Hwang, Sung-Hee Kang, Jiyeon Kim, Hyeon-Joong Park, Chan-Woo Nah, Seung-Yeol J Ginseng Res Articles In the previous report, we have demonstrated that ginsenoside Rc, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside Rh(1) and Rh(2), ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) and ginsenoside epimers such as 20(R)- and 20(S)-ginsenoside Rg(3) in cholesterol-deprived medium. We found that ginsenoside Rh(1) almost restored normal growth of worms in cholesterol-deprived medium in F1 generation. However, supplement of ginsenoside Rh(2) caused a suppression of worm growths in cholesterol-deprived medium. In addition, CK and PPD also slightly restored normal growth of worms in cholesterol-deprived medium but PPT not. In experiments using ginsenoside epimers, supplement of 20(S)- but not 20(R)-ginsenoside Rg(3) in cholesterol-deprived medium also almost restored worm growth. These results indicate that the absence or presence of carbohydrate component at backbone of ginsenoside, the number of carbohydrate attached at carbon-3, and the position of hydroxyl group at carbon-20 of ginsenoside might plays important roles in restoration of worm growth in cholesterol-deprived medium. The Korean Society of Ginseng 2011-09 /pmc/articles/PMC3659541/ /pubmed/23717083 http://dx.doi.org/10.5142/jgr.2011.35.3.375 Text en Copyright ©2011, The Korean Society of Ginseng http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Lee, Joon-Hee
Ahn, Ji-Yun
Shin, Tae-Joon
Choi, Sun-Hye
Lee, Byung-Hwan
Hwang, Sung-Hee
Kang, Jiyeon
Kim, Hyeon-Joong
Park, Chan-Woo
Nah, Seung-Yeol
Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
title Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
title_full Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
title_fullStr Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
title_full_unstemmed Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
title_short Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
title_sort effects of minor ginsenosides, ginsenoside metabolites, and ginsenoside epimers on the growth of caenorhabditis elegans
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659541/
https://www.ncbi.nlm.nih.gov/pubmed/23717083
http://dx.doi.org/10.5142/jgr.2011.35.3.375
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