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Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets

Ginseng, the root of Panax ginseng Meyer, has been used frequently in traditional oriental medicine and is popular globally. Ginsenosides, which are the saponins in ginseng, are the major components having pharmacological and biological activities, including anti-diabetic and anti-tumor activities....

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Autores principales: Lee, Dong-Ha, Cho, Hyun-Jeong, Kang, Hye-Yeon, Rhee, Man Hee, Park, Hwa-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Ginseng 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659562/
https://www.ncbi.nlm.nih.gov/pubmed/23717102
http://dx.doi.org/10.5142/jgr.2012.36.1.40
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author Lee, Dong-Ha
Cho, Hyun-Jeong
Kang, Hye-Yeon
Rhee, Man Hee
Park, Hwa-Jin
author_facet Lee, Dong-Ha
Cho, Hyun-Jeong
Kang, Hye-Yeon
Rhee, Man Hee
Park, Hwa-Jin
author_sort Lee, Dong-Ha
collection PubMed
description Ginseng, the root of Panax ginseng Meyer, has been used frequently in traditional oriental medicine and is popular globally. Ginsenosides, which are the saponins in ginseng, are the major components having pharmacological and biological activities, including anti-diabetic and anti-tumor activities. In this study, we investigated the effects of total saponin from Korean red ginseng (TSKRG) on thrombin-produced thromboxane A(2) (TXA(2)), an aggregating thrombogenic molecule, and its associated microsomal enzymes cyclooxygenase (COX)-1 and TXA(2) synthase (TXAS). Thrombin (0.5 U/mL) increased TXA(2) production up to 169 ng/10(8) platelets as compared with control (0.2 ng/10(8) platelets). However, TSKRG inhibited potently TXA(2) production to the control level in a dose-dependent manner, which was associated with the strong inhibition of COX-1 and TXAS activities in platelet microsomes having cytochrome c reductase activity. The results demonstrate TSKRG is a beneficial traditional oriental medicine in platelet-mediated thrombotic diseases via suppression of COX-1 and TXAS to inhibit production of TXA(2).
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spelling pubmed-36595622013-05-28 Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets Lee, Dong-Ha Cho, Hyun-Jeong Kang, Hye-Yeon Rhee, Man Hee Park, Hwa-Jin J Ginseng Res Articles Ginseng, the root of Panax ginseng Meyer, has been used frequently in traditional oriental medicine and is popular globally. Ginsenosides, which are the saponins in ginseng, are the major components having pharmacological and biological activities, including anti-diabetic and anti-tumor activities. In this study, we investigated the effects of total saponin from Korean red ginseng (TSKRG) on thrombin-produced thromboxane A(2) (TXA(2)), an aggregating thrombogenic molecule, and its associated microsomal enzymes cyclooxygenase (COX)-1 and TXA(2) synthase (TXAS). Thrombin (0.5 U/mL) increased TXA(2) production up to 169 ng/10(8) platelets as compared with control (0.2 ng/10(8) platelets). However, TSKRG inhibited potently TXA(2) production to the control level in a dose-dependent manner, which was associated with the strong inhibition of COX-1 and TXAS activities in platelet microsomes having cytochrome c reductase activity. The results demonstrate TSKRG is a beneficial traditional oriental medicine in platelet-mediated thrombotic diseases via suppression of COX-1 and TXAS to inhibit production of TXA(2). The Korean Society of Ginseng 2012-01 /pmc/articles/PMC3659562/ /pubmed/23717102 http://dx.doi.org/10.5142/jgr.2012.36.1.40 Text en Copyright ©2012, The Korean Society of Ginseng http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Lee, Dong-Ha
Cho, Hyun-Jeong
Kang, Hye-Yeon
Rhee, Man Hee
Park, Hwa-Jin
Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets
title Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets
title_full Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets
title_fullStr Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets
title_full_unstemmed Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets
title_short Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets
title_sort total saponin from korean red ginseng inhibits thromboxane a(2) production associated microsomal enzyme activity in platelets
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659562/
https://www.ncbi.nlm.nih.gov/pubmed/23717102
http://dx.doi.org/10.5142/jgr.2012.36.1.40
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