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Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets
Ginseng, the root of Panax ginseng Meyer, has been used frequently in traditional oriental medicine and is popular globally. Ginsenosides, which are the saponins in ginseng, are the major components having pharmacological and biological activities, including anti-diabetic and anti-tumor activities....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Ginseng
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659562/ https://www.ncbi.nlm.nih.gov/pubmed/23717102 http://dx.doi.org/10.5142/jgr.2012.36.1.40 |
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author | Lee, Dong-Ha Cho, Hyun-Jeong Kang, Hye-Yeon Rhee, Man Hee Park, Hwa-Jin |
author_facet | Lee, Dong-Ha Cho, Hyun-Jeong Kang, Hye-Yeon Rhee, Man Hee Park, Hwa-Jin |
author_sort | Lee, Dong-Ha |
collection | PubMed |
description | Ginseng, the root of Panax ginseng Meyer, has been used frequently in traditional oriental medicine and is popular globally. Ginsenosides, which are the saponins in ginseng, are the major components having pharmacological and biological activities, including anti-diabetic and anti-tumor activities. In this study, we investigated the effects of total saponin from Korean red ginseng (TSKRG) on thrombin-produced thromboxane A(2) (TXA(2)), an aggregating thrombogenic molecule, and its associated microsomal enzymes cyclooxygenase (COX)-1 and TXA(2) synthase (TXAS). Thrombin (0.5 U/mL) increased TXA(2) production up to 169 ng/10(8) platelets as compared with control (0.2 ng/10(8) platelets). However, TSKRG inhibited potently TXA(2) production to the control level in a dose-dependent manner, which was associated with the strong inhibition of COX-1 and TXAS activities in platelet microsomes having cytochrome c reductase activity. The results demonstrate TSKRG is a beneficial traditional oriental medicine in platelet-mediated thrombotic diseases via suppression of COX-1 and TXAS to inhibit production of TXA(2). |
format | Online Article Text |
id | pubmed-3659562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society of Ginseng |
record_format | MEDLINE/PubMed |
spelling | pubmed-36595622013-05-28 Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets Lee, Dong-Ha Cho, Hyun-Jeong Kang, Hye-Yeon Rhee, Man Hee Park, Hwa-Jin J Ginseng Res Articles Ginseng, the root of Panax ginseng Meyer, has been used frequently in traditional oriental medicine and is popular globally. Ginsenosides, which are the saponins in ginseng, are the major components having pharmacological and biological activities, including anti-diabetic and anti-tumor activities. In this study, we investigated the effects of total saponin from Korean red ginseng (TSKRG) on thrombin-produced thromboxane A(2) (TXA(2)), an aggregating thrombogenic molecule, and its associated microsomal enzymes cyclooxygenase (COX)-1 and TXA(2) synthase (TXAS). Thrombin (0.5 U/mL) increased TXA(2) production up to 169 ng/10(8) platelets as compared with control (0.2 ng/10(8) platelets). However, TSKRG inhibited potently TXA(2) production to the control level in a dose-dependent manner, which was associated with the strong inhibition of COX-1 and TXAS activities in platelet microsomes having cytochrome c reductase activity. The results demonstrate TSKRG is a beneficial traditional oriental medicine in platelet-mediated thrombotic diseases via suppression of COX-1 and TXAS to inhibit production of TXA(2). The Korean Society of Ginseng 2012-01 /pmc/articles/PMC3659562/ /pubmed/23717102 http://dx.doi.org/10.5142/jgr.2012.36.1.40 Text en Copyright ©2012, The Korean Society of Ginseng http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Lee, Dong-Ha Cho, Hyun-Jeong Kang, Hye-Yeon Rhee, Man Hee Park, Hwa-Jin Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets |
title | Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets |
title_full | Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets |
title_fullStr | Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets |
title_full_unstemmed | Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets |
title_short | Total Saponin from Korean Red Ginseng Inhibits Thromboxane A(2) Production Associated Microsomal Enzyme Activity in Platelets |
title_sort | total saponin from korean red ginseng inhibits thromboxane a(2) production associated microsomal enzyme activity in platelets |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659562/ https://www.ncbi.nlm.nih.gov/pubmed/23717102 http://dx.doi.org/10.5142/jgr.2012.36.1.40 |
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