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The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children

Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after...

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Autores principales: Lee, Jae Min, Hah, Jeong Ok, Kim, Hee Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Ginseng 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659604/
https://www.ncbi.nlm.nih.gov/pubmed/23717140
http://dx.doi.org/10.5142/jgr.2012.36.4.383
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author Lee, Jae Min
Hah, Jeong Ok
Kim, Hee Sun
author_facet Lee, Jae Min
Hah, Jeong Ok
Kim, Hee Sun
author_sort Lee, Jae Min
collection PubMed
description Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemotherapy or stem cell transplantation for advanced cancer. Thirty patients, who were diagnosed and treated for leukemia and solid cancer at the department of pediatrics and adolescence of the Yeungnam University Hospital from June 2004 to June 2009, were enrolled for the study. The study group consisted of 19 patients who received KRG extract (60 mg/kg/d) for 1 yr and 11 patients who did not receive KRG extract were the control group. Blood samples were collected every 6 mo. Immune assays included circulating lymphocyte subpopulation, serum cytokines (IL- 2, IL-10, IL-12, TNF-alpha, and IFN-gamma), and total concentrations of serum IgG, IgA, and IgM subclasses. Age at diagnosis ranged from 2 mo to 15 yr (median 5 yr). Nine patients received stem cell transplantation. The cytokines of the KRG treated group were decreasing more rapidly than that of the control group. Lymphocyte subpopulations (T cell, B cell, NK cell, T4, T8, and T4/ T8 ratio) and serum immunoglobulin subclasses (IgG, IgA, and IgM) did not show significant differences between the study and the control groups. This study suggests that KRG extract might have a stabilizing effect on the inflammatory cytokines in children with cancer after chemotherapy.
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spelling pubmed-36596042013-05-28 The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children Lee, Jae Min Hah, Jeong Ok Kim, Hee Sun J Ginseng Res Articles Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemotherapy or stem cell transplantation for advanced cancer. Thirty patients, who were diagnosed and treated for leukemia and solid cancer at the department of pediatrics and adolescence of the Yeungnam University Hospital from June 2004 to June 2009, were enrolled for the study. The study group consisted of 19 patients who received KRG extract (60 mg/kg/d) for 1 yr and 11 patients who did not receive KRG extract were the control group. Blood samples were collected every 6 mo. Immune assays included circulating lymphocyte subpopulation, serum cytokines (IL- 2, IL-10, IL-12, TNF-alpha, and IFN-gamma), and total concentrations of serum IgG, IgA, and IgM subclasses. Age at diagnosis ranged from 2 mo to 15 yr (median 5 yr). Nine patients received stem cell transplantation. The cytokines of the KRG treated group were decreasing more rapidly than that of the control group. Lymphocyte subpopulations (T cell, B cell, NK cell, T4, T8, and T4/ T8 ratio) and serum immunoglobulin subclasses (IgG, IgA, and IgM) did not show significant differences between the study and the control groups. This study suggests that KRG extract might have a stabilizing effect on the inflammatory cytokines in children with cancer after chemotherapy. The Korean Society of Ginseng 2012-10 /pmc/articles/PMC3659604/ /pubmed/23717140 http://dx.doi.org/10.5142/jgr.2012.36.4.383 Text en Copyright ©2012, The Korean Society of Ginseng http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Lee, Jae Min
Hah, Jeong Ok
Kim, Hee Sun
The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children
title The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children
title_full The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children
title_fullStr The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children
title_full_unstemmed The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children
title_short The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children
title_sort effect of red ginseng extract on inflammatory cytokines after chemotherapy in children
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659604/
https://www.ncbi.nlm.nih.gov/pubmed/23717140
http://dx.doi.org/10.5142/jgr.2012.36.4.383
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