Cargando…
Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats
To evaluate the effect of the saponin of heat-processed ginseng (Sun ginseng, SG), we investigated the protective effect of SG total saponin fraction against adenine-induced chronic renal failure in rats. SG saponin significantly decreased the levels of urea nitrogen and creatinine in the serum, but...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Ginseng
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659619/ https://www.ncbi.nlm.nih.gov/pubmed/23717161 http://dx.doi.org/10.5142/jgr.2013.37.87 |
_version_ | 1782270475563433984 |
---|---|
author | Kim, Eun Jin Oh, Hyun-A Choi, Hyuck Jai Park, Jeong Hill Kim, Dong-Hyun Kim, Nam Jae |
author_facet | Kim, Eun Jin Oh, Hyun-A Choi, Hyuck Jai Park, Jeong Hill Kim, Dong-Hyun Kim, Nam Jae |
author_sort | Kim, Eun Jin |
collection | PubMed |
description | To evaluate the effect of the saponin of heat-processed ginseng (Sun ginseng, SG), we investigated the protective effect of SG total saponin fraction against adenine-induced chronic renal failure in rats. SG saponin significantly decreased the levels of urea nitrogen and creatinine in the serum, but increased the urinary excretion of urea nitrogen and creatinine, indicating an improvement of renal function. SG saponin also inhibited adenine-induced kidney hypertrophy and edema. SG saponin reduced serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase activities increased by adenine. Based on these findings, the ameliorating effect of SG on chronic renal failure may result from its saponin. |
format | Online Article Text |
id | pubmed-3659619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Ginseng |
record_format | MEDLINE/PubMed |
spelling | pubmed-36596192013-05-28 Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats Kim, Eun Jin Oh, Hyun-A Choi, Hyuck Jai Park, Jeong Hill Kim, Dong-Hyun Kim, Nam Jae J Ginseng Res Articles To evaluate the effect of the saponin of heat-processed ginseng (Sun ginseng, SG), we investigated the protective effect of SG total saponin fraction against adenine-induced chronic renal failure in rats. SG saponin significantly decreased the levels of urea nitrogen and creatinine in the serum, but increased the urinary excretion of urea nitrogen and creatinine, indicating an improvement of renal function. SG saponin also inhibited adenine-induced kidney hypertrophy and edema. SG saponin reduced serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase activities increased by adenine. Based on these findings, the ameliorating effect of SG on chronic renal failure may result from its saponin. The Korean Society of Ginseng 2013-03 /pmc/articles/PMC3659619/ /pubmed/23717161 http://dx.doi.org/10.5142/jgr.2013.37.87 Text en Copyright ©2013, The Korean Society of Ginseng http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Kim, Eun Jin Oh, Hyun-A Choi, Hyuck Jai Park, Jeong Hill Kim, Dong-Hyun Kim, Nam Jae Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats |
title | Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats |
title_full | Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats |
title_fullStr | Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats |
title_full_unstemmed | Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats |
title_short | Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats |
title_sort | heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659619/ https://www.ncbi.nlm.nih.gov/pubmed/23717161 http://dx.doi.org/10.5142/jgr.2013.37.87 |
work_keys_str_mv | AT kimeunjin heatprocessedginsengsaponinamelioratestheadenineinducedrenalfailureinrats AT ohhyuna heatprocessedginsengsaponinamelioratestheadenineinducedrenalfailureinrats AT choihyuckjai heatprocessedginsengsaponinamelioratestheadenineinducedrenalfailureinrats AT parkjeonghill heatprocessedginsengsaponinamelioratestheadenineinducedrenalfailureinrats AT kimdonghyun heatprocessedginsengsaponinamelioratestheadenineinducedrenalfailureinrats AT kimnamjae heatprocessedginsengsaponinamelioratestheadenineinducedrenalfailureinrats |