Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target

Cancer stem cells (CSCs) are a subpopulation generally thought to be responsible for cancer initiation and progression. Because CSCs are often rare in the total tumor cell population and differentiate rapidly when grown in culture, it has been challenging to uncover compounds that selectively target...

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Detalles Bibliográficos
Autores principales: Zhang, Fang, Rothermund, Kristi, Gangadharan, Sajithlal B., Pommier, Yves, Prochownik, Edward V., Lazo, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660065/
https://www.ncbi.nlm.nih.gov/pubmed/22948175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660065/
https://www.ncbi.nlm.nih.gov/pubmed/22948175

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