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New dilemmas in small-cell lung cancer TNM clinical staging

BACKGROUND: Many patients with limited disease (LD) behave similarly to those with extensive disease (ED) from a prognostic point of view. On the other hand, a proportion of patients with ED small-cell lung cancer (SCLC) behave similarly to those with LD. PATIENTS AND METHODS: In this retrospective...

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Detalles Bibliográficos
Autores principales: Zarogoulidis, Konstantinos, Latsios, Dimitrios, Porpodis, Konstantinos, Zarogoulidis, Paul, Darwiche, Kaid, Antoniou, Nick, Hohenforst-Schmidt, Wolfgang, Eleftheriadou, Ellada, Boutsikou, Efimia, Kontakiotis, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660153/
https://www.ncbi.nlm.nih.gov/pubmed/23700372
http://dx.doi.org/10.2147/OTT.S44201
Descripción
Sumario:BACKGROUND: Many patients with limited disease (LD) behave similarly to those with extensive disease (ED) from a prognostic point of view. On the other hand, a proportion of patients with ED small-cell lung cancer (SCLC) behave similarly to those with LD. PATIENTS AND METHODS: In this retrospective study analysis, 764 patients with proven SCLC were included and managed with the same therapeutic protocols. Of these patients, 278 (36.4%) had LD, while 486 (63.6%) had ED. RESULTS: No statistically significant difference was observed for survival for IA and IB disease stages (P = 0.254) and between IIA and IIB stages (P = 0.256) according to the new tumor, node, metastasis (TNM) staging classification classification. In addition, no statistical significant difference was observed for survival between patients with (IIA + IIB) and IIIA (P = 0.951), (IIA + IIIA, P = 0.658), and (IIB + IIIA, P = 0.573) stages. Statistical significant difference was observed for survival among the LD SCLC patients with (IA + IB), (IIA + IIB + IIIA), and IIIB stages (P < 0.001). Similarly, statistical significance was observed for ED SCLC patients with (IIA + IIB + IIIA), IIIB, and IV stages (P < 0.001). CONCLUSIONS: Although stratification of SCLC patients in LD and ED is generally satisfactory, the TNM staging system is recommended for more detailed prognostic information and treatment evaluation in these patients.