Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer

BACKGROUND: Epidermal growth factor receptor (EGFR) gene mutations identify patients with non-small cell lung cancer (NSCLC) who have a high likelihood of benefiting from treatment with anti-EGFR tyrosine kinase inhibitors. Sanger sequencing is widely used for mutation detection but can be technical...

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Detalles Bibliográficos
Autores principales: O’Donnell, Patrick, Ferguson, Jane, Shyu, Johnny, Current, Robert, Rehage, Taraneh, Tsai, Julie, Christensen, Mari, Tran, Ha Bich, Chien, Sean Shih-Chang, Shieh, Felice, Wei, Wen, Lawrence, H Jeffrey, Wu, Lin, Schilling, Robert, Bloom, Kenneth, Maltzman, Warren, Anderson, Steven, Soviero, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660201/
https://www.ncbi.nlm.nih.gov/pubmed/23621958
http://dx.doi.org/10.1186/1471-2407-13-210

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