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Protection against Myocardial Ischemia-Reperfusion Injury at Onset of Type 2 Diabetes in Zucker Diabetic Fatty Rats Is Associated with Altered Glucose Oxidation

BACKGROUND: Inhibition of glucose oxidation during initial reperfusion confers protection against ischemia-reperfusion (IR) injury in the heart. Mitochondrial metabolism is altered with progression of type 2 diabetes (T2DM). We hypothesized that the metabolic alterations present at onset of T2DM ind...

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Detalles Bibliográficos
Autores principales: Povlsen, Jonas Agerlund, Løfgren, Bo, Dalgas, Christian, Birkler, Rune Isak Dupont, Johannsen, Mogens, Støttrup, Nicolaj Brejnholt, Bøtker, Hans Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660588/
https://www.ncbi.nlm.nih.gov/pubmed/23704975
http://dx.doi.org/10.1371/journal.pone.0064093

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