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Characterization of Cognitive Deficits in Rats Overexpressing Human Alpha-Synuclein in the Ventral Tegmental Area and Medial Septum Using Recombinant Adeno-Associated Viral Vectors
Intraneuronal inclusions containing alpha-synuclein (a-syn) constitute one of the pathological hallmarks of Parkinson's disease (PD) and are accompanied by severe neurodegeneration of A9 dopaminergic neurons located in the substantia nigra. Although to a lesser extent, A10 dopaminergic neurons...
Autores principales: | Hall, Hélène, Jewett, Michael, Landeck, Natalie, Nilsson, Nathalie, Schagerlöf, Ulrika, Leanza, Giampiero, Kirik, Deniz |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660601/ https://www.ncbi.nlm.nih.gov/pubmed/23705016 http://dx.doi.org/10.1371/journal.pone.0064844 |
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