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Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations
The antihyperlipidemic activity of resinoids of guggul (Commiphora mukul/Commiphora wightii), belonging to family Burseraceae (Genus: Commiphora), collected from different parts of India (Gujarat, Madhya Pradesh and Rajasthan), was studied on cholesterol-rich high fat diet-induced model of hyperlipi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660868/ https://www.ncbi.nlm.nih.gov/pubmed/23716870 http://dx.doi.org/10.4103/0250-474X.108417 |
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author | Siddiqui, M. Z. Mazumder, P. M. |
author_facet | Siddiqui, M. Z. Mazumder, P. M. |
author_sort | Siddiqui, M. Z. |
collection | PubMed |
description | The antihyperlipidemic activity of resinoids of guggul (Commiphora mukul/Commiphora wightii), belonging to family Burseraceae (Genus: Commiphora), collected from different parts of India (Gujarat, Madhya Pradesh and Rajasthan), was studied on cholesterol-rich high fat diet-induced model of hyperlipidemia in rats. The resinoids of these exudates were prepared in ethyl acetate and ethyl alcohol. The physicochemical characterization of these resinoids was carried out to determine their appearance, %yield, %moisture, %ash, acid value (mg/KOH/g), saponification value (mg/KOH/g), ester value and iodine value (g/g). Antihyperlipidemic study was carried out on all resinoids in high fat diet induced model of hyperlipidemia in Wistar albino rats. The result demonstrated that the resinoids of exudates of Commiphora wightii and Commiphora mukul, collected from Gujarat and extracted in ethyl acetate, and the resinoids of exudates of Commiphora mukul, collected from Madhya Pradesh and extracted in ethyl acetate, possessed significantly higher antihyperlipidemic activity compared with other resinoids, which may be due to regional/geographical variations. |
format | Online Article Text |
id | pubmed-3660868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36608682013-05-28 Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations Siddiqui, M. Z. Mazumder, P. M. Indian J Pharm Sci Research Paper The antihyperlipidemic activity of resinoids of guggul (Commiphora mukul/Commiphora wightii), belonging to family Burseraceae (Genus: Commiphora), collected from different parts of India (Gujarat, Madhya Pradesh and Rajasthan), was studied on cholesterol-rich high fat diet-induced model of hyperlipidemia in rats. The resinoids of these exudates were prepared in ethyl acetate and ethyl alcohol. The physicochemical characterization of these resinoids was carried out to determine their appearance, %yield, %moisture, %ash, acid value (mg/KOH/g), saponification value (mg/KOH/g), ester value and iodine value (g/g). Antihyperlipidemic study was carried out on all resinoids in high fat diet induced model of hyperlipidemia in Wistar albino rats. The result demonstrated that the resinoids of exudates of Commiphora wightii and Commiphora mukul, collected from Gujarat and extracted in ethyl acetate, and the resinoids of exudates of Commiphora mukul, collected from Madhya Pradesh and extracted in ethyl acetate, possessed significantly higher antihyperlipidemic activity compared with other resinoids, which may be due to regional/geographical variations. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3660868/ /pubmed/23716870 http://dx.doi.org/10.4103/0250-474X.108417 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Siddiqui, M. Z. Mazumder, P. M. Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations |
title | Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations |
title_full | Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations |
title_fullStr | Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations |
title_full_unstemmed | Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations |
title_short | Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations |
title_sort | comparative study of hypolipidemic profile of resinoids of commiphora mukul/commiphora wightii from different geographical locations |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660868/ https://www.ncbi.nlm.nih.gov/pubmed/23716870 http://dx.doi.org/10.4103/0250-474X.108417 |
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