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The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review
OBJECTIVE: Previous studies have evaluated the associations of TNF-α, IL-10 gene polymorphisms and susceptibility to pSS, but the results remained controversial. To assess the associations between TNF-α-308, IL-10-1082, -819, -592 polymorphisms and pSS risk, a meta-analysis was conducted. METHOD: Th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661073/ https://www.ncbi.nlm.nih.gov/pubmed/23723980 http://dx.doi.org/10.1371/journal.pone.0063401 |
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author | Qin, Baodong Wang, Jiaqi Liang, Yan Yang, Zaixing Zhong, Renqian |
author_facet | Qin, Baodong Wang, Jiaqi Liang, Yan Yang, Zaixing Zhong, Renqian |
author_sort | Qin, Baodong |
collection | PubMed |
description | OBJECTIVE: Previous studies have evaluated the associations of TNF-α, IL-10 gene polymorphisms and susceptibility to pSS, but the results remained controversial. To assess the associations between TNF-α-308, IL-10-1082, -819, -592 polymorphisms and pSS risk, a meta-analysis was conducted. METHOD: The available articles were searched in PubMed, EMBASE and MEDLINE. ORs with 95% CIs were calculated to determine the strength of associations by fixed-effects or random-effects models. The data about IL-10-1082, -819, -592 polymorphisms were analyzed in the additive, dominant and recessive modes. The associations between haplotypes of IL-10 gene and susceptibility to pSS were also assessed. RESULTS: A total of 9 relevant studies were identified in the meta-analyses. TNF-α-308 A allele was significantly associated with pSS (OR = 1.8, 95% CI: 1.53–2.13). The IL-10 -1082 G allele and the genotype “GCC/ATA” were identified as a candidate genetic risk factor for pSS. Under the dominant model for −819 and −582, the overall ORs suggested that individuals with genotype (CC+TC) or (CC+AC) may have a 59% increased risk of pSS in Caucasians population (OR = 1.59, 95% CI:1.09–1.23). Besides, the genotype “ATA/ATA” may be a protective factor against the development of pSS in Caucasians (OR = 0.40, 95% CI:0.19–0.84). CONCLUSION: The meta-analysis demonstrated TNF-α-308 A, IL-10-1082 G allele were significantly associated with pSS susceptibility, supporting these alleles were predisposing factors for pSS. In Caucasian population, the genotype “ATA/ATA” may be a protective factors. |
format | Online Article Text |
id | pubmed-3661073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36610732013-05-30 The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review Qin, Baodong Wang, Jiaqi Liang, Yan Yang, Zaixing Zhong, Renqian PLoS One Research Article OBJECTIVE: Previous studies have evaluated the associations of TNF-α, IL-10 gene polymorphisms and susceptibility to pSS, but the results remained controversial. To assess the associations between TNF-α-308, IL-10-1082, -819, -592 polymorphisms and pSS risk, a meta-analysis was conducted. METHOD: The available articles were searched in PubMed, EMBASE and MEDLINE. ORs with 95% CIs were calculated to determine the strength of associations by fixed-effects or random-effects models. The data about IL-10-1082, -819, -592 polymorphisms were analyzed in the additive, dominant and recessive modes. The associations between haplotypes of IL-10 gene and susceptibility to pSS were also assessed. RESULTS: A total of 9 relevant studies were identified in the meta-analyses. TNF-α-308 A allele was significantly associated with pSS (OR = 1.8, 95% CI: 1.53–2.13). The IL-10 -1082 G allele and the genotype “GCC/ATA” were identified as a candidate genetic risk factor for pSS. Under the dominant model for −819 and −582, the overall ORs suggested that individuals with genotype (CC+TC) or (CC+AC) may have a 59% increased risk of pSS in Caucasians population (OR = 1.59, 95% CI:1.09–1.23). Besides, the genotype “ATA/ATA” may be a protective factor against the development of pSS in Caucasians (OR = 0.40, 95% CI:0.19–0.84). CONCLUSION: The meta-analysis demonstrated TNF-α-308 A, IL-10-1082 G allele were significantly associated with pSS susceptibility, supporting these alleles were predisposing factors for pSS. In Caucasian population, the genotype “ATA/ATA” may be a protective factors. Public Library of Science 2013-05-21 /pmc/articles/PMC3661073/ /pubmed/23723980 http://dx.doi.org/10.1371/journal.pone.0063401 Text en © 2013 Qin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Qin, Baodong Wang, Jiaqi Liang, Yan Yang, Zaixing Zhong, Renqian The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review |
title | The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review |
title_full | The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review |
title_fullStr | The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review |
title_full_unstemmed | The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review |
title_short | The Association between TNF-α, IL-10 Gene Polymorphisms and Primary Sjögren’s Syndrome: A Meta-Analysis and Systemic Review |
title_sort | association between tnf-α, il-10 gene polymorphisms and primary sjögren’s syndrome: a meta-analysis and systemic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661073/ https://www.ncbi.nlm.nih.gov/pubmed/23723980 http://dx.doi.org/10.1371/journal.pone.0063401 |
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