Cargando…

WAT is a functional adipocyte?

In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Church, Christopher, Horowitz, Mark, Rodeheffer, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661122/
https://www.ncbi.nlm.nih.gov/pubmed/23700509
http://dx.doi.org/10.4161/adip.19132
_version_ 1782270630097321984
author Church, Christopher
Horowitz, Mark
Rodeheffer, Matthew
author_facet Church, Christopher
Horowitz, Mark
Rodeheffer, Matthew
author_sort Church, Christopher
collection PubMed
description In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocytes are not the only cell type in mammals that can accumulate lipid droplets. The ectopic accumulation of lipid in non-adipose tissues including the liver, skeletal muscle, bone, pancreas, and heart in combination with its excessive accumulation in adipose tissue contributes to metabolic disease. Determining the lipid processing components that are necessary and sufficiently for lipid accumulation in adipose and non-adipose tissues, in addition to endocrine function, will lead to a clearer definition of an adipocyte.
format Online
Article
Text
id pubmed-3661122
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36611222013-05-22 WAT is a functional adipocyte? Church, Christopher Horowitz, Mark Rodeheffer, Matthew Adipocyte Review In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocytes are not the only cell type in mammals that can accumulate lipid droplets. The ectopic accumulation of lipid in non-adipose tissues including the liver, skeletal muscle, bone, pancreas, and heart in combination with its excessive accumulation in adipose tissue contributes to metabolic disease. Determining the lipid processing components that are necessary and sufficiently for lipid accumulation in adipose and non-adipose tissues, in addition to endocrine function, will lead to a clearer definition of an adipocyte. Landes Bioscience 2012-01-01 /pmc/articles/PMC3661122/ /pubmed/23700509 http://dx.doi.org/10.4161/adip.19132 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Church, Christopher
Horowitz, Mark
Rodeheffer, Matthew
WAT is a functional adipocyte?
title WAT is a functional adipocyte?
title_full WAT is a functional adipocyte?
title_fullStr WAT is a functional adipocyte?
title_full_unstemmed WAT is a functional adipocyte?
title_short WAT is a functional adipocyte?
title_sort wat is a functional adipocyte?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661122/
https://www.ncbi.nlm.nih.gov/pubmed/23700509
http://dx.doi.org/10.4161/adip.19132
work_keys_str_mv AT churchchristopher watisafunctionaladipocyte
AT horowitzmark watisafunctionaladipocyte
AT rodeheffermatthew watisafunctionaladipocyte