Cargando…
WAT is a functional adipocyte?
In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. Ho...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661122/ https://www.ncbi.nlm.nih.gov/pubmed/23700509 http://dx.doi.org/10.4161/adip.19132 |
_version_ | 1782270630097321984 |
---|---|
author | Church, Christopher Horowitz, Mark Rodeheffer, Matthew |
author_facet | Church, Christopher Horowitz, Mark Rodeheffer, Matthew |
author_sort | Church, Christopher |
collection | PubMed |
description | In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocytes are not the only cell type in mammals that can accumulate lipid droplets. The ectopic accumulation of lipid in non-adipose tissues including the liver, skeletal muscle, bone, pancreas, and heart in combination with its excessive accumulation in adipose tissue contributes to metabolic disease. Determining the lipid processing components that are necessary and sufficiently for lipid accumulation in adipose and non-adipose tissues, in addition to endocrine function, will lead to a clearer definition of an adipocyte. |
format | Online Article Text |
id | pubmed-3661122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36611222013-05-22 WAT is a functional adipocyte? Church, Christopher Horowitz, Mark Rodeheffer, Matthew Adipocyte Review In vertebrates, adipose tissue is the main storage site for lipids within specialized lipid-laden mature adipocytes. While many species have evolved cells capable of lipid storage, the adipocyte represents a unique specialized cell involved in fuel storage, endocrine, nervous and immune function. However, the adipocytes are not the only cell type in mammals that can accumulate lipid droplets. The ectopic accumulation of lipid in non-adipose tissues including the liver, skeletal muscle, bone, pancreas, and heart in combination with its excessive accumulation in adipose tissue contributes to metabolic disease. Determining the lipid processing components that are necessary and sufficiently for lipid accumulation in adipose and non-adipose tissues, in addition to endocrine function, will lead to a clearer definition of an adipocyte. Landes Bioscience 2012-01-01 /pmc/articles/PMC3661122/ /pubmed/23700509 http://dx.doi.org/10.4161/adip.19132 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Church, Christopher Horowitz, Mark Rodeheffer, Matthew WAT is a functional adipocyte? |
title | WAT is a functional adipocyte? |
title_full | WAT is a functional adipocyte? |
title_fullStr | WAT is a functional adipocyte? |
title_full_unstemmed | WAT is a functional adipocyte? |
title_short | WAT is a functional adipocyte? |
title_sort | wat is a functional adipocyte? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661122/ https://www.ncbi.nlm.nih.gov/pubmed/23700509 http://dx.doi.org/10.4161/adip.19132 |
work_keys_str_mv | AT churchchristopher watisafunctionaladipocyte AT horowitzmark watisafunctionaladipocyte AT rodeheffermatthew watisafunctionaladipocyte |