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Proteomics in the characterization of adipose dysfunction in obesity
Adipose tissue plays a central role in body weight homeostasis, inflammation, and insulin resistance via serving as a fat-buffering system, regulating lipid storage and mobilization and releasing a large range of adipokines and cytokines. Adipose tissue is also the major inflammation-initiated site...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661126/ https://www.ncbi.nlm.nih.gov/pubmed/23700508 http://dx.doi.org/10.4161/adip.19129 |
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author | Brockman, David Chen, Xiaoli |
author_facet | Brockman, David Chen, Xiaoli |
author_sort | Brockman, David |
collection | PubMed |
description | Adipose tissue plays a central role in body weight homeostasis, inflammation, and insulin resistance via serving as a fat-buffering system, regulating lipid storage and mobilization and releasing a large range of adipokines and cytokines. Adipose tissue is also the major inflammation-initiated site in obesity. Adipose-derived adipokines and cytokines are known to be involved in the modulation of a wide range of important physiological processes, particularly immune response, glucose and lipid homeostasis and insulin resistance. Adipose tissue dysfunction, characterized by an imbalanced secretion of pro- and anti-inflammatory adipokines and cytokines, decreased insulin-stimulated glucose uptake, dysregulation of lipid storage and release and mitochondrial dysfunction, has been linked to obesity and its associated metabolic disorders. Proteomic technology has been a powerful tool for identifying key components of the adipose proteome, which may contribute to the pathogenesis of adipose tissue dysfunction in obesity. In this review, we summarized the recent advances in the proteomic characterization of adipose tissue and discussed the identified proteins that potentially play important roles in insulin resistance and lipid homeostasis. |
format | Online Article Text |
id | pubmed-3661126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36611262013-05-22 Proteomics in the characterization of adipose dysfunction in obesity Brockman, David Chen, Xiaoli Adipocyte Review Adipose tissue plays a central role in body weight homeostasis, inflammation, and insulin resistance via serving as a fat-buffering system, regulating lipid storage and mobilization and releasing a large range of adipokines and cytokines. Adipose tissue is also the major inflammation-initiated site in obesity. Adipose-derived adipokines and cytokines are known to be involved in the modulation of a wide range of important physiological processes, particularly immune response, glucose and lipid homeostasis and insulin resistance. Adipose tissue dysfunction, characterized by an imbalanced secretion of pro- and anti-inflammatory adipokines and cytokines, decreased insulin-stimulated glucose uptake, dysregulation of lipid storage and release and mitochondrial dysfunction, has been linked to obesity and its associated metabolic disorders. Proteomic technology has been a powerful tool for identifying key components of the adipose proteome, which may contribute to the pathogenesis of adipose tissue dysfunction in obesity. In this review, we summarized the recent advances in the proteomic characterization of adipose tissue and discussed the identified proteins that potentially play important roles in insulin resistance and lipid homeostasis. Landes Bioscience 2012-01-01 /pmc/articles/PMC3661126/ /pubmed/23700508 http://dx.doi.org/10.4161/adip.19129 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Brockman, David Chen, Xiaoli Proteomics in the characterization of adipose dysfunction in obesity |
title | Proteomics in the characterization of adipose dysfunction in obesity |
title_full | Proteomics in the characterization of adipose dysfunction in obesity |
title_fullStr | Proteomics in the characterization of adipose dysfunction in obesity |
title_full_unstemmed | Proteomics in the characterization of adipose dysfunction in obesity |
title_short | Proteomics in the characterization of adipose dysfunction in obesity |
title_sort | proteomics in the characterization of adipose dysfunction in obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661126/ https://www.ncbi.nlm.nih.gov/pubmed/23700508 http://dx.doi.org/10.4161/adip.19129 |
work_keys_str_mv | AT brockmandavid proteomicsinthecharacterizationofadiposedysfunctioninobesity AT chenxiaoli proteomicsinthecharacterizationofadiposedysfunctioninobesity |