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Orexin receptor-1 mediates brown fat developmental differentiation
Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding, wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely orexin receptor-1 (OXR1) and orexin receptor-2 (OXR2). OX-deficient mice are sensitive to obesity despite being hypophagic. The obeso...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661127/ https://www.ncbi.nlm.nih.gov/pubmed/23700511 http://dx.doi.org/10.4161/adip.18965 |
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author | Sellayah, Dyan Sikder, Devanjan |
author_facet | Sellayah, Dyan Sikder, Devanjan |
author_sort | Sellayah, Dyan |
collection | PubMed |
description | Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding, wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely orexin receptor-1 (OXR1) and orexin receptor-2 (OXR2). OX-deficient mice are sensitive to obesity despite being hypophagic. The obesogenic effect of OX-deletion is due to brown adipose tissue (BAT) dysfunction, a defect that originates during fetal growth. Brown preadipocytes in OX-null mice display undifferentiated histological appearance and fail to support both diet- and cold-induced thermogenesis. We show that the OXR1-null mice phenocopies the differentiation defect observed in the ligand-null mice indicating that OXR1 relays OX’s differentiation and thermogenic function. Consistent with this, OX fails to induce differentiation in cultured OXR1-null preadipocytes. Thus, OX signaling via OXR1 constitutes an important thermoregulatory mechanism that defends against cold and obesity. |
format | Online Article Text |
id | pubmed-3661127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36611272013-05-22 Orexin receptor-1 mediates brown fat developmental differentiation Sellayah, Dyan Sikder, Devanjan Adipocyte Brief Report Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding, wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely orexin receptor-1 (OXR1) and orexin receptor-2 (OXR2). OX-deficient mice are sensitive to obesity despite being hypophagic. The obesogenic effect of OX-deletion is due to brown adipose tissue (BAT) dysfunction, a defect that originates during fetal growth. Brown preadipocytes in OX-null mice display undifferentiated histological appearance and fail to support both diet- and cold-induced thermogenesis. We show that the OXR1-null mice phenocopies the differentiation defect observed in the ligand-null mice indicating that OXR1 relays OX’s differentiation and thermogenic function. Consistent with this, OX fails to induce differentiation in cultured OXR1-null preadipocytes. Thus, OX signaling via OXR1 constitutes an important thermoregulatory mechanism that defends against cold and obesity. Landes Bioscience 2012-01-01 /pmc/articles/PMC3661127/ /pubmed/23700511 http://dx.doi.org/10.4161/adip.18965 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Brief Report Sellayah, Dyan Sikder, Devanjan Orexin receptor-1 mediates brown fat developmental differentiation |
title | Orexin receptor-1 mediates brown fat developmental differentiation |
title_full | Orexin receptor-1 mediates brown fat developmental differentiation |
title_fullStr | Orexin receptor-1 mediates brown fat developmental differentiation |
title_full_unstemmed | Orexin receptor-1 mediates brown fat developmental differentiation |
title_short | Orexin receptor-1 mediates brown fat developmental differentiation |
title_sort | orexin receptor-1 mediates brown fat developmental differentiation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661127/ https://www.ncbi.nlm.nih.gov/pubmed/23700511 http://dx.doi.org/10.4161/adip.18965 |
work_keys_str_mv | AT sellayahdyan orexinreceptor1mediatesbrownfatdevelopmentaldifferentiation AT sikderdevanjan orexinreceptor1mediatesbrownfatdevelopmentaldifferentiation |