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Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance
Obesity is associated with a low-grade, chronic inflammation that promotes the development of a variety of diseases, most notably type 2 diabetes. A number of cell types of the innate and adaptive immune systems have been implicated in this process. Recent studies have focused on the role of natural...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661135/ https://www.ncbi.nlm.nih.gov/pubmed/23700548 http://dx.doi.org/10.4161/adip.22296 |
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author | Wu, Lan Van Kaer, Luc |
author_facet | Wu, Lan Van Kaer, Luc |
author_sort | Wu, Lan |
collection | PubMed |
description | Obesity is associated with a low-grade, chronic inflammation that promotes the development of a variety of diseases, most notably type 2 diabetes. A number of cell types of the innate and adaptive immune systems have been implicated in this process. Recent studies have focused on the role of natural killer T (NKT) cells, a subset of T lymphocytes that react with lipids, in the development of obesity-associated diseases. These studies have shown that invariant NKT (iNKT) cells, a population of NKT cells expressing a semi-invariant T cell receptor, become rapidly activated in response to lipid excess, and that these cells influence the capacity of other leukocytes to produce cytokines during the progression of obesity. The role of NKT cells in obesity-associated inflammation and insulin resistance has been investigated using NKT cell-deficient animals, adoptive transfer of NKT cells and an iNKT cell agonist. While divergent results have been obtained, it is now clear that NKT cells can modulate the inflammatory milieu in obesity, suggesting that these cells could be targeted for therapeutic intervention in obesity-associated diseases. |
format | Online Article Text |
id | pubmed-3661135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36611352013-05-22 Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance Wu, Lan Van Kaer, Luc Adipocyte Mini Review Obesity is associated with a low-grade, chronic inflammation that promotes the development of a variety of diseases, most notably type 2 diabetes. A number of cell types of the innate and adaptive immune systems have been implicated in this process. Recent studies have focused on the role of natural killer T (NKT) cells, a subset of T lymphocytes that react with lipids, in the development of obesity-associated diseases. These studies have shown that invariant NKT (iNKT) cells, a population of NKT cells expressing a semi-invariant T cell receptor, become rapidly activated in response to lipid excess, and that these cells influence the capacity of other leukocytes to produce cytokines during the progression of obesity. The role of NKT cells in obesity-associated inflammation and insulin resistance has been investigated using NKT cell-deficient animals, adoptive transfer of NKT cells and an iNKT cell agonist. While divergent results have been obtained, it is now clear that NKT cells can modulate the inflammatory milieu in obesity, suggesting that these cells could be targeted for therapeutic intervention in obesity-associated diseases. Landes Bioscience 2013-01-01 2013-01-01 /pmc/articles/PMC3661135/ /pubmed/23700548 http://dx.doi.org/10.4161/adip.22296 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Mini Review Wu, Lan Van Kaer, Luc Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance |
title | Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance |
title_full | Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance |
title_fullStr | Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance |
title_full_unstemmed | Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance |
title_short | Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance |
title_sort | contribution of lipid-reactive natural killer t cells to obesity-associated inflammation and insulin resistance |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661135/ https://www.ncbi.nlm.nih.gov/pubmed/23700548 http://dx.doi.org/10.4161/adip.22296 |
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