Immune effects of 5-fluorouracil: Ambivalence matters

Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLR...

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Detalles Bibliográficos
Autores principales: Ghiringhelli, François, Bruchard, Melanie, Apetoh, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661151/
https://www.ncbi.nlm.nih.gov/pubmed/23802066
http://dx.doi.org/10.4161/onci.23139
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author Ghiringhelli, François
Bruchard, Melanie
Apetoh, Lionel
author_facet Ghiringhelli, François
Bruchard, Melanie
Apetoh, Lionel
author_sort Ghiringhelli, François
collection PubMed
description Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting T(H)17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression.
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spelling pubmed-36611512013-06-25 Immune effects of 5-fluorouracil: Ambivalence matters Ghiringhelli, François Bruchard, Melanie Apetoh, Lionel Oncoimmunology Author's View Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting T(H)17 responses that compromise anticancer immunity. This underscores the need to combine 5-FU with NLRP3 inhibitors to prevent tumor progression. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661151/ /pubmed/23802066 http://dx.doi.org/10.4161/onci.23139 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ghiringhelli, François
Bruchard, Melanie
Apetoh, Lionel
Immune effects of 5-fluorouracil: Ambivalence matters
title Immune effects of 5-fluorouracil: Ambivalence matters
title_full Immune effects of 5-fluorouracil: Ambivalence matters
title_fullStr Immune effects of 5-fluorouracil: Ambivalence matters
title_full_unstemmed Immune effects of 5-fluorouracil: Ambivalence matters
title_short Immune effects of 5-fluorouracil: Ambivalence matters
title_sort immune effects of 5-fluorouracil: ambivalence matters
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661151/
https://www.ncbi.nlm.nih.gov/pubmed/23802066
http://dx.doi.org/10.4161/onci.23139
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